N⁶-Ethyl-adenosin | 14357-08-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N⁶-Ethyl-adenosin
• 英文别名: N⁶-ethyl-adenosine；2-[6-(Ethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 14357-08-5
• 化学式: C₁₂H₁₇N₅O₄
• 分子量: 295.298
• InChiKey: SHXVYOLWYFZWKE-UHFFFAOYSA-N

物化性质

• 熔点：
  191-192 °C(Solv: water (7732-18-5))
• 沸点：
  642.9±65.0 °C(Predicted)
• 密度：
  1.76±0.1 g/cm3(Predicted)
• 溶解度：
  二甲基亚砜：75mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• N6-substituted adenosine derivatives and N6-substituted adenine derivatives and uses thereof
  申请人：Shi Jiangong

  公开号：US10174033B2

  公开（公告）日：2019-01-08

  The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

  本发明提供了 N6-取代腺苷衍生物和 N6-取代腺嘌呤衍生物、其制造方法、包含上述化合物的药物组合物，以及这些化合物在制造治疗失眠、抽搐、癫痫和帕金森病以及预防和治疗痴呆症的药物和保健产品中的用途。
• Methods and Compositions for Treating Pain
  申请人：Academia Sinica

  公开号：US20170224716A1

  公开（公告）日：2017-08-10

  The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.