3-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[2-[2,3,4-tris[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropanoyl]oxyethoxy]ethoxy]pentoxy]ethoxy]ethyl] propanedioate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[2-[2,3,4-tris[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropanoyl]oxyethoxy]ethoxy]pentoxy]ethoxy]ethyl] propanedioate
• 化学式: C₄₉H₆₄N₄O₃₂
• 分子量: 1221.0
• InChiKey: BZMODFOCHBFSBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  85
• 可旋转键数：
  51
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  434
• 氢给体数：
  0
• 氢受体数：
  32

文献信息

• BIOCOMPATIBLE HYDROGEL TREATMENTS FOR RETINAL DETACHMENT
  申请人：Medicus Biosciences LLC

  公开号：US20140248231A1

  公开（公告）日：2014-09-04

  Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.
• US20140271767A1
  申请人：——

  公开号：US20140271767A1

  公开（公告）日：2014-09-18
• Biocompatible Hydrogel Polymer Formulations for the Controlled Delivery of Biomolecules
  申请人：Askari Syed H.

  公开号：US20140302051A1

  公开（公告）日：2014-10-09

  Provided herein are biocompatible hydrogel polymers capable of gelling in vivo comprising a therapeutic agent such as a protein or other biomolecule and kits comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and at least one therapeutic agent. The biocompatible hydrogel polymer is bioabsorbable and releases the therapeutic agent at a target site, avoiding systemic exposure and achieving a controlled delivery.
• SOLID POLYGLYCOL-BASED BIOCOMPATIBLE PRE-FORMULATION
  申请人：Medicus Biosciences LLC

  公开号：US20150272987A1

  公开（公告）日：2015-10-01

  Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.
• US9072809B2
  申请人：——

  公开号：US9072809B2

  公开（公告）日：2015-07-07