2-(4-Propan-2-ylphenoxy)pyrazine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-Propan-2-ylphenoxy)pyrazine
• 英文别名: 2-(4-propan-2-ylphenoxy)pyrazine
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.26
• InChiKey: ZHWZJOPBMMNMKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• TRIAZINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS
  申请人：Purdue Pharma L.P.

  公开号：US20140249128A1

  公开（公告）日：2014-09-04

  The present disclosure provides substituted triazine carboxamides of Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A 1 , X, A 2 , E, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供了式I的替代三嗪羧酰胺化合物：和其药用可接受的盐和溶剂，其中A1、X、A2、E和Z的定义如规范中所述。本公开还涉及使用式I的化合物来治疗对钠通道阻滞有响应的疾病。本公开的化合物特别适用于治疗疼痛。
• Triazine carboxamides as sodium channel blockers
  申请人：Purdue Pharma L.P.

  公开号：US10000475B2

  公开（公告）日：2018-06-19

  The present disclosure provides substituted triazine carboxamides of Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, E, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供了式 I 的取代三嗪羧酰胺： 及其药学上可接受的盐和溶液，其中 A1、X、A2、E 和 Z 的定义如说明书所述。本公开还涉及使用式 I 的化合物治疗对阻断钠通道有反应的疾病。本公开的化合物尤其适用于治疗疼痛。
• US9120786B2
  申请人：——

  公开号：US9120786B2

  公开（公告）日：2015-09-01