2-Pyrazin-2-yloxyethylcarbamic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Pyrazin-2-yloxyethylcarbamic acid
• 英文别名: 2-pyrazin-2-yloxyethylcarbamic acid
• 化学式: C₇H₉N₃O₃
• 分子量: 183.16
• InChiKey: CHTOKZMOKKHCFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  84.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-HT1A receptors
  申请人：NEUROLIXIS

  公开号：US10562853B2

  公开（公告）日：2020-02-18

  The invention concerns compounds that possess a high affinity at 5-HT1A receptors and an agonist efficacy, as measured by Emax values from a cellular activation assay, that is higher than that of the compounds described in prior art. The capacity of the compounds of the invention to activate an effector protein complex is higher than that the most efficacious agonist described in prior art. Compounds of the invention also exhibit an exceptionally high selectivity (Ki ratio greater than 1000-fold) with respect, in particular, to dopamine D2 receptors and adrenergic receptors of the alpha1 subtype. This selectivity which constitutes a great advantage since it means that the compounds will avoid inducing (central and peripheral) effects associated with activating or inhibiting such receptors.

  本发明所涉及的化合物对 5-HT1A 受体具有高亲和力，并且根据细胞活化实验的 Emax 值衡量，其激动剂功效高于现有技术中所述的化合物。本发明化合物激活效应蛋白复合物的能力高于现有技术中最有效的激动剂。本发明的化合物还具有极高的选择性（Ki 比值大于 1000 倍），特别是对多巴胺 D2 受体和α1 亚型肾上腺素能受体。这种选择性具有很大的优势，因为它意味着本发明的化合物可以避免引起与激活或抑制这些受体相关的（中枢和外周）效应。
• PYRROLOTRIAZINES AS POTASSIUM ION CHANNEL INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2970296B1

  公开（公告）日：2016-12-21
• COMPOUNDS FOR TREATING DISORDERS SENSITIVE TO SEROTONINERGIC REGULATION CONTROLLED BY THE 5-HT1A RECEPTORS
  申请人：Neurolixis

  公开号：EP3475268A1

  公开（公告）日：2019-05-01
• US20140256719A1
  申请人：——

  公开号：US20140256719A1

  公开（公告）日：2014-09-11
• US9050345B2
  申请人：——

  公开号：US9050345B2

  公开（公告）日：2015-06-09