1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxypyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxypyrimidine-2,4-dione
• 化学式: C₉H₁₂N₂O₇
• 分子量: 260.2
• InChiKey: BHLSXKJMMJDRJP-XVFCMESISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Rhizoma Arisaematis Extracts and Uses Thereof for Wound-Healing Effects
  申请人：Ip Nancy Yuk-Yu

  公开号：US20150004261A1

  公开（公告）日：2015-01-01

  Provided are water and alcohol extracts of Rhizoma arisaematis , compounds isolated from Rhizoma arisaematis (such as 3-O-(9,12-octadecadienoyl)-glyceryl-β-D-galactopyranoside, N-(β-D-ribofuranos-1-yl)-phenylalanine, and adenosine), pharmaceutical compositions comprising the aforementioned ingredients, as well as uses thereof for promoting wound healing. In one embodiment, the pharmaceutical composition is a topical formulation, such as a cream, ointment, foam, lotion, plaster, gel, and emulsion.
• METHODS OF DETECTING NEUROTOXIN USING SYNAPTIC ACTIVITY
  申请人：MCNUTT Patrick

  公开号：US20150362482A1

  公开（公告）日：2015-12-17

  The present invention relates to methods of detecting neurotoxin in a sample. The methods of the present invention are highly sensitive and specific, rapid, and clinically relevant with minimal cost. The methods of the present invention use isolated neurons capable of networked synaptic activity, which allows each step of the natural toxin intoxication process to occur, mimicking the clinical manifestation of toxin intoxication. This networked synaptic activity provides rapid and highly sensitive neurotoxin detection. The methods are also directed to detecting neurotoxin neutralizing agents and neurotoxin identity.
• [EN] METHODS OF DETECTING NEUROTOXIN USING SYNAPTIC ACTIVITY<br/>[FR] PROCÉDÉS DE DÉTECTION DE NEUROTOXINE À L'AIDE D'UNE ACTIVITÉ SYNAPTIQUE
  申请人：US OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF

  公开号：WO2014138663A1

  公开（公告）日：2014-09-12

  The present invention relates to methods of detecting neurotoxin in a sample. The methods of the present invention are highly sensitive and specific, rapid, and clinically relevant with minimal cost. The methods of the present invention use isolated neurons capable of networked synaptic activity, which allows each step of the natural toxin intoxication process to occur, mimicking the clinical manifestation of toxin intoxication. This networked synaptic activity provides rapid and highly sensitive neurotoxin detection. The methods are also directed to detecting neurotoxin neutralizing agents and neurotoxin identity.