2-(Hydroxymethyl)-6-(6-methoxy-2-methylidenechromen-7-yl)oxyoxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Hydroxymethyl)-6-(6-methoxy-2-methylidenechromen-7-yl)oxyoxane-3,4,5-triol
• 英文别名: 2-(hydroxymethyl)-6-(6-methoxy-2-methylidenechromen-7-yl)oxyoxane-3,4,5-triol
• 化学式: C₁₇H₂₀O₈
• 分子量: 352.3
• InChiKey: UNIZKXYFCNEORG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• COMPOSITION FOR PREVENTING, IMPROVING OR TREATING POSTMENOPAUSAL OSTEOPOROSIS COMPRISING SCOPOLIN
  申请人：AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US20170252363A1

  公开（公告）日：2017-09-07

  Provided is a pharmaceutical composition for preventing, improving, or treating postmenopausal osteoporosis in women, the composition including, as an active ingredient, scopolin, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein scopolin has good efficacy in stimulating osteoblast differentiation, and is also effective in inhibiting a reduction in bone density after menopause, low density in a bone microstructure, a reduction in a bone formation marker in the blood, and an increase in a bone resorption marker. Therefore, scopolin and the composition including the same as an active ingredient are expected to be useful as pharmaceutical preparations for the prevention, improvement, or treatment of postmenopausal osteoporosis in women.
• US8828954B2
  申请人：——

  公开号：US8828954B2

  公开（公告）日：2014-09-09