4-Amino-2,8-dimethylnonane-3,7-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Amino-2,8-dimethylnonane-3,7-dione
• 英文别名: 4-amino-2,8-dimethylnonane-3,7-dione
• 化学式: C₁₁H₂₁NO₂
• 分子量: 199.29
• InChiKey: XRJLHTYZIQKJJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US20200071275A1

  公开（公告）日：2020-03-05

  Provided herein are compounds and pharmaceutical compositions useful in modulating kinase activity, and related diseases. Also provided herein are methods of treating an eye disease or disorder in a subject. Also provided herein are methods of reducing intraocular pressure in a subject. Also provided herein are methods of modulating kinase activity in a cell. Also provided herein are methods of making the compounds provided herein, and compounds useful for the preparation of the compounds provided herein.

  本文提供了一些化合物和制药组合物，可用于调节激酶活性及相关疾病。本文还提供了一种治疗主题眼疾或疾病的方法。本文还提供了一种降低主题眼内压的方法。本文还提供了一种在细胞中调节激酶活性的方法。本文还提供了制备本文提供的化合物的方法，以及制备本文提供的化合物所需的化合物。
• Isoquinoline-steroid conjugates and uses thereof
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US11059789B2

  公开（公告）日：2021-07-13

  Provided herein are compounds and pharmaceutical compositions useful in modulating kinase activity, and related diseases. Also provided herein are methods of treating an eye disease or disorder in a subject. Also provided herein are methods of reducing intraocular pressure in a subject. Also provided herein are methods of modulating kinase activity in a cell. Also provided herein are methods of making the compounds provided herein, and compounds useful for the preparation of the compounds provided herein.

  本文提供了用于调节激酶活性及相关疾病的化合物和药物组合物。本文还提供了治疗受试者眼部疾病或失调的方法。本文还提供了降低受试者眼压的方法。本文还提供了调节细胞中激酶活性的方法。本文还提供了制造本文提供的化合物的方法，以及用于制备本文提供的化合物的化合物。
• US20140256660A1
  申请人：——

  公开号：US20140256660A1

  公开（公告）日：2014-09-11
• [EN] ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS ISOQUINOLINE-STÉROÏDE ET UTILISATIONS ASSOCIÉES
  申请人：AERIE PHARMACEUTICALS INC

  公开号：WO2020047496A1

  公开（公告）日：2020-03-05

  Provided herein are compounds and pharmaceutical compositions useful in modulating kinase activity, and related diseases. Also provided herein are methods of treating an eye disease or disorder in a subject. Also provided herein are methods of reducing intraocular pressure in a subject. Also provided herein are methods of modulating kinase activity in a cell. Also provided herein are methods of making the compounds provided herein, and compounds useful for the preparation of the compounds provided herein.
• [EN] IN VIVO ASSEMBLY OF ASGPR BINDING THERAPEUTICS<br/>[FR] ASSEMBLAGE IN VIVO D'AGENTS THÉRAPEUTIQUES DE LIAISON À ASGPR
  申请人：AVILAR THERAPEUTICS INC

  公开号：WO2022035997A1

  公开（公告）日：2022-02-17

  Compounds are provided that assemble together in vivo to form an ASGPR-binding compound that has an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein.