4-Aminooctane-3,6-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Aminooctane-3,6-dione
• 英文别名: 4-aminooctane-3,6-dione
• 化学式: C₈H₁₅NO₂
• 分子量: 157.21
• InChiKey: YQCPNZOTMUPIET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] ANTIBIOTIC CONJUGATES LINKED WITH STEROID DRUGS<br/>[FR] CONJUGUÉS ANTIBIOTIQUES LIÉS À DES MÉDICAMENTS STÉROÏDES
  申请人：ALLERGAN INC

  公开号：WO2014138375A1

  公开（公告）日：2014-09-12

  The present invention describes novel single drug entities, formed by the linkage of an antibiotic with a steroidal drug via a linker. Upon topical application to the eye, the conjugate would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
• [EN] IN VIVO ASSEMBLY OF ASGPR BINDING THERAPEUTICS<br/>[FR] ASSEMBLAGE IN VIVO D'AGENTS THÉRAPEUTIQUES DE LIAISON À ASGPR
  申请人：AVILAR THERAPEUTICS INC

  公开号：WO2022035997A1

  公开（公告）日：2022-02-17

  Compounds are provided that assemble together in vivo to form an ASGPR-binding compound that has an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein.