hydron;(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: hydron;(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol
• 化学式: C12H23O11+
• 分子量: 343.3
• InChiKey: HDTRYLNUVZCQOY-LIZSDCNHSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -5.28
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  9
• 氢受体数：
  11

文献信息

• [EN] TREHALOSE HYDROGELS FOR STABILIZATION AND DELIVERY OF PROTEINS<br/>[FR] HYDROGELS DE TRÉHALOSE POUR LA STABILISATION ET L'ADMINISTRATION DE PROTÉINES
  申请人：UNIV CALIFORNIA

  公开号：WO2016025551A1

  公开（公告）日：2016-02-18

  Trehalose-based hydrogels and methods of making such hydrogels are disclosed. Specifically, a method of creating a trehalose-based hydrogel, comprising the steps of: a) forming a trehalose homopolymer or co-polymer; b) preparing a cross-linker; and c) reacting the trehalose homopolymer or co-polymer with the cross-linker to form the trehalose-based hydrogel.

  本发明揭示了基于海藻糖的水凝胶及其制备方法。具体而言，本发明揭示了制备基于海藻糖的水凝胶的方法，包括以下步骤：a）形成海藻糖同聚物或共聚物；b）准备交联剂；c）将海藻糖同聚物或共聚物与交联剂反应以形成基于海藻糖的水凝胶。
• Trehalose hydrogels for stabilization and delivery of proteins
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10662295B2

  公开（公告）日：2020-05-26

  Trehalose-based hydrogels and methods of making such hydrogels are disclosed. Specifically, a method of creating a trehalose-based hydrogel, comprising the steps of: a) forming a trehalose homopolymer or co-polymer; b) preparing a cross-linker; and c) reacting the trehalose homopolymer or co-polymer with the cross-linker to form the trehalose-based hydrogel.

  本发明公开了以曲卤糖为基础的水凝胶和制造这种水凝胶的方法。具体地说，一种制造妥尔糖基水凝胶的方法，包括以下步骤：a) 形成妥尔糖均聚物或共聚物；b) 制备交联剂；c) 妥尔糖均聚物或共聚物与交联剂反应形成妥尔糖基水凝胶。
• TREHALOSE HYDROGELS FOR STABILIZATION AND DELIVERY OF PROTEINS
  申请人：The Regents of the University of California

  公开号：EP3180030A1

  公开（公告）日：2017-06-21
• US20140271601A1
  申请人：——

  公开号：US20140271601A1

  公开（公告）日：2014-09-18
• CROSSLINKABLE TREHALOSE FOR THE COVALENT INCORPORATION IN HYDROGELS AND METHODS OF USE
  申请人：INVIVO THERAPEUTICS CORPORATION

  公开号：US20180015167A1

  公开（公告）日：2018-01-18

  Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.