[4-[2-[4-carbamoyl-2-ethynyl-6-(2-morpholin-4-ylethyl)anilino]pyrimidin-4-yl]oxynaphthalen-2-yl]-(4-methylphenyl)-(propan-2-ylcarbamoyl)-(1H-pyrazol-5-yl)azanium

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [4-[2-[4-carbamoyl-2-ethynyl-6-(2-morpholin-4-ylethyl)anilino]pyrimidin-4-yl]oxynaphthalen-2-yl]-(4-methylphenyl)-(propan-2-ylcarbamoyl)-(1H-pyrazol-5-yl)azanium
• 化学式: C43H44N9O4+
• 分子量: 750.9
• InChiKey: SAJNIHURYAXGFW-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  56
• 可旋转键数：
  13
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  160
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• [EN] UREA DERIVATIVES USEFUL AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'URÉE UTILISÉS EN TANT QU'INHIBITEURS DE KINASE
  申请人：RESPIVERT LTD

  公开号：WO2014162126A1

  公开（公告）日：2014-10-09

  There are provided compounds of formula I, wherein R1A to R1E, R2 to R5, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了化学式I的化合物，其中R1A至R1E，R2至R5，L和X1至X3的含义如描述中所示，这些化合物具有抗炎活性（例如通过抑制p38丝裂原活化蛋白激酶酶家族中的一个或多个成员；Syk激酶；和酪氨酸激酶Src家族的成员之一）并且在治疗中有用，包括在药物组合中，特别是用于治疗炎症性疾病，包括肺部、眼睛和肠道的炎症性疾病。
• [EN] DIARYL UREA DERIVATIVES AS P38 KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE DIARYLE-URÉE EN TANT QU'INHIBITEURS DE KINASE P38
  申请人：RESPIVERT LTD

  公开号：WO2016051187A1

  公开（公告）日：2016-04-07

  There are provided compounds of formula I, wherein R1A to R1E, R2 to R4, R5a, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了具有公式I的化合物，其中R1A至R1E，R2至R4，R5a，L和X1至X3的含义如描述中所示，这些化合物具有抗炎活性（例如，通过抑制p38丝裂原活化蛋白激酶酶家族中的一个或多个成员；Syk激酶；和酪氨酸激酶Src家族成员）并用于治疗，包括在药物组合中，特别是用于治疗包括肺部、眼睛和肠道炎症疾病在内的炎症性疾病。
• [EN] N-PHENYL-3-QUINAZOLIN-6-YL-BENZAMIDE DERIVATIVES AS P38 KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE N-PHÉNYL-3-QUINAZOLIN-6-YL-BENZAMIDE EN TANT QU'INHIBITEURS DE KINASE P38
  申请人：RESPIVERT LTD

  公开号：WO2016051186A1

  公开（公告）日：2016-04-07

  There are provided compounds of formula I, wherein R1A to R1E, R2, R3, R4A to R4C, L and X have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了公式I的化合物，其中R1A至R1E，R2，R3，R4A至R4C，L和X的含义如描述中所给，这些化合物具有抗炎活性（例如通过抑制p38丝裂原活化蛋白激酶酶家族的一个或多个成员，Syk激酶以及酪氨酸激酶Src家族的成员之一），并且可用于治疗，包括在药物组合中，特别是用于治疗炎症性疾病，包括肺部，眼睛和肠道的炎症性疾病。
• UREA DERIVATIVES USEFUL AS KINASE INHIBITORS
  申请人：Respivert Limited

  公开号：EP2981535A1

  公开（公告）日：2016-02-10
• KINASE INHIBITORS
  申请人：Respivert Limited

  公开号：EP2970190A1

  公开（公告）日：2016-01-20