Azane;1,5-dibromo-3-methylidenepentane-2,4-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Azane;1,5-dibromo-3-methylidenepentane-2,4-dione
• 英文别名: azane;1,5-dibromo-3-methylidenepentane-2,4-dione
• 化学式: C6H12Br2N2O2
• 分子量: 303.98
• InChiKey: AHFBHLKPVYQPOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.79
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  36.1
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ANTIBODIES CAPABLE OF SPECIFICALLY BINDING TWO EPITOPES ON TISSUE FACTOR PATHWAY INHIBITOR
  申请人：NOVO NORDISK A/S

  公开号：US20160032012A1

  公开（公告）日：2016-02-04

  The application discloses a combination of two monospecific TFPI antibodies, wherein one antibody is capable of specifically binding TFPI (1-181) and the other antibody is capable of specifically binding TFPI (182-276), as well as bispecific anti-TFPI antibodies derived from two such monospecific antibodies. Both the combination of the two monospecific antibodies and the bispecific antibody strongly enhance thrombin generation by neutralising full length TFPIα, even where the concentration of TFPI is abnormally elevated.

  该申请公开了两种单克隆TFPI抗体的组合，其中一种抗体能够特异性地结合TFPI（1-181），另一种抗体能够特异性地结合TFPI（182-276），以及由这两种单克隆抗体衍生的双特异性抗-TFPI抗体。两种单克隆抗体的组合和双特异性抗体均通过中和全长TFPIα显著增强凝血酶生成，即使TFPI的浓度异常升高。
• Antibodies capable of specifically binding two epitopes on tissue factor pathway inhibitor
  申请人：Novo Nordisk A/S

  公开号：US10717784B2

  公开（公告）日：2020-07-21

  The application discloses a combination of two monospecific TFPI antibodies, wherein one antibody is capable of specifically binding TFPI (1-181) and the other antibody is capable of specifically binding TFPI (182-276), as well as bispecific anti-TFPI antibodies derived from two such monospecific antibodies. Both the combination of the two monospecific antibodies and the bispecific antibody strongly enhance thrombin generation by neutralising full length TFPIα, even where the concentration of TFPI is abnormally elevated.

  该申请公开了两种单特异性 TFPI 抗体（其中一种抗体能特异性结合 TFPI（1-181），另一种抗体能特异性结合 TFPI（182-276）））的组合，以及由两种此类单特异性抗体衍生的双特异性抗 TFPI 抗体。即使在 TFPI 浓度异常升高的情况下，两种单特异性抗体和双特异性抗体的组合也能通过中和全长 TFPIα 而强烈促进凝血酶的生成。
• KERZE MIT EINEM KOMPOSTIERBAREN KUNSTSTOFFELEMENT
  申请人：Cup Candle GmbH

  公开号：EP3464530A2

  公开（公告）日：2019-04-10
• US9896513B2
  申请人：——

  公开号：US9896513B2

  公开（公告）日：2018-02-20
• [EN] ANTIBODIES CAPABLE OF SPECIFICALLY BINDING TWO EPITOPES ON TISSUE FACTOR PATHWAY INHIBITOR<br/>[FR] ANTICORPS APTES À LIER SPÉCIFIQUEMENT DEUX ÉPITOPES SUR UN INHIBITEUR DE LA VOIE D'UN FACTEUR TISSULAIRE
  申请人：NOVO NORDISK AS

  公开号：WO2014140240A1

  公开（公告）日：2014-09-18

  The application discloses a combination of two monospecific TFPI antibodies, wherein one antibody is capable of specifically binding TFPI (1-181) and the other antibody is capable of specifically binding TFPI (182-276), as well as bispecific anti-TFPI antibodies derived from two such monospecific antibodies. Both the combination of the two monospecific antibodies and the bispecific antibody strongly enhance thrombin generation by neutralising full length TFPIα, even where the concentration of TFPI is abnormally elevated.