1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine derivatives characterized by having a lower alkyl, cyclo(lower)alkyl, phenyl or substituted phenyl at position 1 of the nucleus and optionally further substituted at position 2 of the nucleus with a lower alkyl, cyclo(lower)alkyl, phenyl(lower)alkylene or 2-(indole-3-yl)ethyl are disclosed. The derivatives are useful antidepressant agents. Methods for their preparation also are disclosed.
JIRKOVSKY, I.;BAUDY, R., SYNTHESIS, BRD, 1981, N 6, 481-483
作者:JIRKOVSKY, I.、BAUDY, R.
DOI:——
日期:——
US4188389A
申请人:——
公开号:US4188389A
公开(公告)日:1980-02-12
[EN] 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME<br/>[FR] AZA-HÉTÉROCYCLIQUE À 6 ÉLÉMENTS CONTENANT DES COMPOSÉS MODULATEURS DE RÉCEPTEURS OPIOÏDES DELTA, ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
申请人:TREVENA INC
公开号:WO2017040545A1
公开(公告)日:2017-03-09
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.