1-(2-Methoxyethyl)cyclohexan-1-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-Methoxyethyl)cyclohexan-1-ol
• 英文别名: 1-(2-methoxyethyl)cyclohexan-1-ol
• 化学式: C₉H₁₈O₂
• 分子量: 158.24
• InChiKey: VVVGPOUIUMMZLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ACYLAMINOCYCLOALKYL COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF DOPAMINE D3 RECEPTOR
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：EP2970146A1

  公开（公告）日：2016-01-20
• [EN] ACYLAMINOCYCLOALKYL COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF DOPAMINE D3 RECEPTOR<br/>[FR] COMPOSÉS D'ACYLAMINOCYCLOALKYLE APPROPRIÉS POUR LE TRAITEMENT DE TROUBLES RÉPONDANT À LA MODULATION DU RÉCEPTEUR D3 DE LA DOPAMINE
  申请人：ABBVIE DEUTSCHLAND

  公开号：WO2014140246A1

  公开（公告）日：2014-09-18

  The present invention relates to novel acylaminocycloalkyl compounds, in particular to the compounds of the formula I as described herein and to their salts and N-oxides. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor. In formula I, the variables have the following meanings: m is 1 or 2, n is 1 or 2, A is selected from the group consisting of CH2, CH2CH2, CHFCH2 and CF2CH2, R1 is an oxygen containing cyclic radical selected such as C3-C6 cycloalkyl, which carries one or two oxygen containing radicals selected from the group consisting of OH, C1-C2-alkoxy, fluorinated C1-C2-alkoxy, and a carbonyl oxygen,, R2 is selected from the group consisting of hydrogen, OH and fluorine, R3a is selected from the group consisting of hydrogen and methyl, R3b is selected from the group consisting of hydrogen and methyl, R4 is branched C4-C6 alkyl or branched fluorinated C4-C6 alkyl, and R5 is inter alia C1-C6 alkyl, fluorinated C1-C3 alkyl, C1-C2-alkoxy-C1-C4-alkyl, fluorinated C1-C2-alkoxy-C1-C4-alkyl, hydroxy-C1-C4-alkyl, fluorinated hydroxy-C1-C4-alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, fluorinated C3-C5 cycloalkyl, etc.