Cyclobutane;ethane-1,2-diol;3-methoxyprop-1-ene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Cyclobutane;ethane-1,2-diol;3-methoxyprop-1-ene
• 英文别名: cyclobutane;ethane-1,2-diol;3-methoxyprop-1-ene
• 化学式: C10H22O3
• 分子量: 190.28
• InChiKey: PRVCWYCEUORYFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.35
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• DOSAGE FORM COMPRISING CRIZOTINIB
  申请人：ratiopharm GmbH

  公开号：EP2968167A1

  公开（公告）日：2016-01-20
• Dosage Form Comprising Crizotinib
  申请人：RATIOPHARM GMBH

  公开号：US20160022661A1

  公开（公告）日：2016-01-28

  The invention relates to a method of preparing a tablet, preferably a tablet for immediate release and having a high drug load, containing crizotinib in form of the free base and lubricant, both in specific amounts. The invention further relates to a tablet obtainable by said method.
• [EN] DOSAGE FORM COMPRISING CRIZOTINIB<br/>[FR] FORME DOSIFIÉE COMPRENANT DU CRIZOTINIB
  申请人：RATIOPHARM GMBH

  公开号：WO2014140159A1

  公开（公告）日：2014-09-18

  The invention relates to a method of preparing a tablet, preferably a tablet for immediate release and having a high drug load, containing crizotinib in form of the free base and lubricant, both in specific amounts. The invention further relates to a tablet obtainable by said method.