2-[(4-chloro-2-methyl-1H-indol-5-yl)oxy]-6-(1,1-dioxothian-4-yl)-N-[5-[(E)-prop-1-enyl]-1H-pyrazol-3-yl]pyrimidin-4-amine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(4-chloro-2-methyl-1H-indol-5-yl)oxy]-6-(1,1-dioxothian-4-yl)-N-[5-[(E)-prop-1-enyl]-1H-pyrazol-3-yl]pyrimidin-4-amine
• 化学式: C₂₄H₂₅ClN₆O₃S
• 分子量: 513.0
• InChiKey: JJWZAEIWAUCHBL-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Substituted indol-5-ol derivatives and their therapeutic applications
  申请人：NantBioScience, Inc.

  公开号：US10245261B2

  公开（公告）日：2019-04-02

  The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.

  本发明一般涉及使用化合物治疗各种失调、疾病和病理状况，更具体地说，涉及使用取代的吲哚-5-醇衍生物调节蛋白激酶和治疗蛋白激酶介导的疾病。
• SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
  申请人：NantBioScience, Inc.

  公开号：US20170189400A1

  公开（公告）日：2017-07-06

  The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
• US9458137B2
  申请人：——

  公开号：US9458137B2

  公开（公告）日：2016-10-04
• [EN] SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] DÉRIVÉS INDOL-5-OL SUBSTITUÉS ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：NANTBIO INC

  公开号：WO2014145403A1

  公开（公告）日：2014-09-18

  The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.