2,3-Dimethyl-2,3-bis[(2-methylpropan-2-yl)oxy]butane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-Dimethyl-2,3-bis[(2-methylpropan-2-yl)oxy]butane
• 英文别名: 2,3-dimethyl-2,3-bis[(2-methylpropan-2-yl)oxy]butane
• 化学式: C₁₄H₃₀O₂
• 分子量: 230.39
• InChiKey: YJHSOWAYNHVZNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Boron-Containing Diacylhydrazines
  申请人：Intrexon Corporation

  公开号：US20150322092A1

  公开（公告）日：2015-11-12

  The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

  本公开提供具有I式的含硼二酰肼化合物及其药学上可接受的盐和溶剂化物，其中R1、R2、R3、R4和R5的定义如规范中所述。本公开还提供了使用含硼二酰肼化合物的ecdysone受体基础的诱导基因表达系统。因此，本公开适用于基因治疗、疾病治疗、大规模生产蛋白质和抗体、基于细胞的筛选测定、功能基因组学、蛋白质组学、代谢组学和调控转基因生物的特征等应用，其中需要控制基因表达水平。
• Boron-Containing Diacylhydrazine Compounds
  申请人：Intrexon Corporation

  公开号：US20160083403A1

  公开（公告）日：2016-03-24

  The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R 4 , and R 5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

  本公开提供具有化学式I的含硼二酰肼化合物及其药学上可接受的盐和溶剂化物，其中A、R4和R5的定义如规范中所述。本公开还提供了使用含硼二酰肼类化合物的蜕皮激素受体诱导基因表达系统。因此，本公开对于基因治疗、疾病治疗、大规模蛋白质和抗体的生产、基于细胞的筛选分析、功能基因组学、蛋白质组学、代谢组学以及调节转基因生物的特征等应用非常有用，其中对基因表达水平的控制是必要的。
• US20140274954A1
  申请人：——

  公开号：US20140274954A1

  公开（公告）日：2014-09-18
• US9127024B2
  申请人：——

  公开号：US9127024B2

  公开（公告）日：2015-09-08
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  申请人：——

  公开号：US9512148B2

  公开（公告）日：2016-12-06