4-methyl-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methyl-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine
• 化学式: C₇H₉N₃O
• 分子量: 151.17
• InChiKey: JQEJIMSDRQXEKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Boron-Containing Diacylhydrazines
  申请人：Intrexon Corporation

  公开号：US20150322092A1

  公开（公告）日：2015-11-12

  The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

  本公开提供具有I式的含硼二酰肼化合物及其药学上可接受的盐和溶剂化物，其中R1、R2、R3、R4和R5的定义如规范中所述。本公开还提供了使用含硼二酰肼化合物的ecdysone受体基础的诱导基因表达系统。因此，本公开适用于基因治疗、疾病治疗、大规模生产蛋白质和抗体、基于细胞的筛选测定、功能基因组学、蛋白质组学、代谢组学和调控转基因生物的特征等应用，其中需要控制基因表达水平。
• Novel Imidazol-piperidinyl Derivatives as Modulators of Kinase Activity
  申请人：LAN Ruoxi

  公开号：US20150239902A1

  公开（公告）日：2015-08-27

  The invention provides novel imidazol-piperidinyl derivatives of formula (I) in which R 1 , R 2 , X 1 , X 2 , X 3 , X 4 and n have the meanings indicated in above, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

  本发明提供了公式（I）中新颖的咪唑-哌啶衍生物，其中R1，R2，X1，X2，X3，X4和n具有上述所示的含义，以及它们的制造和用于治疗过度增殖性疾病，如癌症的用途。
• Novel Heterocyclic Derivatives as Modulators of Kinase Activity
  申请人：LAN Ruoxi

  公开号：US20150274750A1

  公开（公告）日：2015-10-01

  The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R 1 , R 2 , W, X 1 , X 2 , X 3 , X 4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

  本发明提供了公式（I）的新型咪唑-哌啶衍生物，其中R1，R2，W，X1，X2，X3，X4和n具有公式I中所示的含义，并且其制备和用于治疗增生性疾病，如癌症。
• IMIDAZOL-PIPERIDINYL DERIVATIVES AS MODULATORS OF KINASE ACTIVITY
  申请人：Merck Patent GmbH

  公开号：EP3299362A1

  公开（公告）日：2018-03-28

  The invention provides novel imidazol-piperidinyl derivatives of formula (I) in which R1, R2, X1, X2, X3, X4 and n have the meanings indicated in above, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

  本发明提供了式 (I) 的新型咪唑-哌啶基衍生物 其中 R1、R2、X1、X2、X3、X4 和 n 具有上述含义、 以及它们在治疗过度增殖性疾病（如癌症）中的制造和用途。
• NOVEL IMIDAZOL-PIPERIDINYL DERIVATIVES AS MODULATORS OF KINASE ACTIVITY
  申请人：Merck Patent GmbH

  公开号：EP2920154B1

  公开（公告）日：2017-10-11