N-[4-(2-fluoro-4-formylphenoxy)pyridin-2-yl]pyrrolidine-1-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[4-(2-fluoro-4-formylphenoxy)pyridin-2-yl]pyrrolidine-1-carboxamide
• 化学式: C₁₇H₁₆FN₃O₃
• 分子量: 329.32
• InChiKey: HGASJYKPPAPLME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] IMIDAZOLIDINONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES<br/>[FR] IMIDAZOLIDINONES ET ANALOGUES À ACTIVITÉS ANTI-CANCER ET ANTI-PROLIFÉRATION
  申请人：DECIPHERA PHARMACEUTICALS LLC

  公开号：WO2014145015A2

  公开（公告）日：2014-09-18

  Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-IR), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c- FMS, c-KIT, or PDGFR kinases.