3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-ol | 1174234-12-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-ol
• 英文别名: 3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolan-2-ol；3,4-Bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolan-2-ol
• CAS: 1174234-12-8
• 化学式: C₂₆H₂₈O₅
• 分子量: 420.505
• InChiKey: NAQUAXSCBJPECG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (3R,4R,5R)-3,4-Bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-yl acetate 在 aluminum oxide 作用下， 以 甲醇 为溶剂， 反应 14.0h， 以85%的产率得到3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-ol
  参考文献：
  名称：

  Regioselective heterogeneous O-deacylation of polyacylated sugars

  摘要：

  DOI：

  10.1016/s0008-6215(00)90208-8

文献信息

• PYRAZOLOTRIAZOLYL NUCLEOSIDE ANALOGUES AND OLIGONUCLEOTIDES COMPRISING THEM
  申请人：Bio-Lab Ltd.

  公开号：US20150141490A1

  公开（公告）日：2015-05-21

  The present invention relates to pyrazolotriazolyl nucleoside analogues, oligonucleotide comprising them, and uses thereof. Further the invention relates to a method for reducing gene expression in a cell comprising transfecting the cell with such an oligonucleotide. It has been found, in accordance with the present invention, that certain pyrazolotriazolyl-based nucleoside analogues such as 8-[3′-(2-cyanoethyl)-(N,Ndiisopropyl)]-phosphoramidite-(2′-deoxy-5′-dimethoxytrity 1-13-D-ribofuranozyl)-4-N-benzoylamino)-pyrazolo[1,5a]-1,3,5-triazine, can be incorporated into oligonucleotides, substituting natural purine nucleosides and imparting acid stability and nuclease stability to the oligonucleotide. Furthermore, oligonucleotides comprising one or more such nucleoside analogues are capable of hybridizing with oligonucleotides having complementary sequences thereto in which no such analogues are incorporated.
• US9994604B2
  申请人：——

  公开号：US9994604B2

  公开（公告）日：2018-06-12
• Regioselective heterogeneous O-deacylation of polyacylated sugars
  作者：Jacob Herzig、Abraham Nudelman

  DOI：10.1016/s0008-6215(00)90208-8

  日期：1986.9