1-N'-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)-1-N-methylcyclopropane-1,1-dicarboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-N'-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)-1-N-methylcyclopropane-1,1-dicarboxamide
• 化学式: C₂₉H₂₆FN₃O₅
• 分子量: 515.5
• InChiKey: XRKQBIDGDLLMGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  90
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DU CANCER
  申请人：KANDULA MAHESH

  公开号：WO2014141057A2

  公开（公告）日：2014-09-18

  The invention relates to the compounds of formula I, formula II and formula III or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II or formula III; and methods for treating or preventing cancer may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of bladder cancer, brain tumors, breast cancer, cervical cancer, colon/ colorectal cancer, endometrial cancer, esophageal cancer, gallbladder cancer, head and neck cancer, kidney cancer, leukemia, liver cancer, lung cancer, lymphoma, mesothelioma, cervical cancer.