1-(4-Aminooxyphenyl)-2-methylpropan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Aminooxyphenyl)-2-methylpropan-1-one
• 英文别名: 1-(4-aminooxyphenyl)-2-methylpropan-1-one
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.22
• InChiKey: DBDJTUYCHUUUAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SITE-SPECIFIC ANTIBODY-DRUG CONJUGATION THROUGH GLYCOENGINEERING
  申请人：Genzyme Corporation

  公开号：US20140294867A1

  公开（公告）日：2014-10-02

  The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

  本公开提供了结合多肽（例如抗体）及其效应物基团共轭物（例如抗体药物共轭物或ADCs），其中包括结合多肽的天然或工程糖醛中的位点特异性设计的药物-糖醛连接。本公开还提供了编码抗原结合多肽的核酸、重组表达载体和宿主细胞，用于制备这种抗原结合多肽。还提供了使用本文所披露的抗原结合多肽治疗疾病的方法。
• HYPERGLYCOSYLATED BINDING POLYPEPTIDES
  申请人：Genzyme Corporation

  公开号：EP3424956A1

  公开（公告）日：2019-01-09

  Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

  提供了包含 CH1 结构域（例如人 IgG1 CH1 结构域）的结合多肽（例如抗体）及其效应分子共轭物，其中根据 Kabat 编号，CH1 结构域在氨基酸位置 114 有一个工程化的 N-连接糖基化位点。此外，还提供了编码抗原结合多肽的核酸、重组表达载体和用于制造这种抗原结合多肽的宿主细胞。还提供了使用本文公开的抗原结合多肽治疗疾病的方法。
• SITE-SPECIFIC GLYCOENGINEERING OF TARGETING MOIETIES
  申请人：Genzyme Corporation

  公开号：EP4015535A1

  公开（公告）日：2022-06-22

  The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

  目前公开的内容提供了结合多肽（如抗体）及其靶向分子共轭物，包括结合多肽的本地或工程聚糖内的位点特异性工程聚糖连接。本公开还提供了编码抗原结合多肽的核酸、重组表达载体和宿主细胞，用于制造这种抗原结合多肽。还提供了使用本文公开的抗原结合多肽治疗疾病的方法。
• Fc containing polypeptides with altered glycosylation and reduced effector function
  申请人：Genzyme Corporation

  公开号：US10836813B2

  公开（公告）日：2020-11-17

  Provided are binding polypeptides (e.g., antibodies), and drug conjugates thereof, comprising an Fc domain with an altered glycosylation profile and reduced effector function. In particular embodiment, the Fc domain comprises: an asparagine residue at amino acid position 298, according to EU numbering; and a serine or threonine residue at amino acid position 300, according to EU numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

  本文提供了结合多肽（如抗体）及其药物共轭物，它们包含一个具有改变的糖基化特征和降低的效应功能的Fc结构域。在特定的实施方案中，Fc 结构域包括：根据欧盟编号，位于氨基酸位置 298 的天冬酰胺残基；以及根据欧盟编号，位于氨基酸位置 300 的丝氨酸或苏氨酸残基。此外，还提供了编码抗原结合多肽的核酸、重组表达载体和用于制造这种抗原结合多肽的宿主细胞。还提供了使用本文公开的抗原结合多肽治疗疾病的方法。
• Site-specific glycoengineering of targeting moieties
  申请人：Genzyme Corporation

  公开号：US10995148B2

  公开（公告）日：2021-05-04

  The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

  目前公开的内容提供了结合多肽（如抗体）及其靶向分子共轭物，包括结合多肽的本地或工程聚糖内的位点特异性工程聚糖连接。目前公开的内容还提供了编码抗原结合多肽的核酸、重组表达载体以及用于制造这种抗原结合多肽的宿主细胞。还提供了使用本文公开的抗原结合多肽治疗疾病的方法。