Cys-Gly-cysteamine | 695196-86-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cys-Gly-cysteamine
• 英文别名: L-Cysteinyl-N-(2-sulfanylethyl)glycinamide；(2R)-2-amino-N-[2-oxo-2-(2-sulfanylethylamino)ethyl]-3-sulfanylpropanamide
• CAS: 695196-86-2
• 化学式: C₇H₁₅N₃O₂S₂
• 分子量: 237.347
• InChiKey: ALJARKCQOMYEHE-YFKPBYRVSA-N

物化性质

• 沸点：
  546.3±50.0 °C(Predicted)
• 密度：
  1.261±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  86.2
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Fmoc-L-丙氨酸 、 N-FMOC-S-三苯甲基-L-高半胱氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 在 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) 、 N,N-二异丙基乙胺 、 哌啶 、 三异丙基硅烷 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.67h， 生成 Cys-Gly-cysteamine
  参考文献：
  名称：

  Conductance Titration of Single-Peptide Molecules

  摘要：

  We have measured the conductance of single peptides covalently bonded to two Au electrodes via S-Au bonds by repeatedly forming a large number of molecular junctions. The conductance decreases exponentially with the peptide length, with a decay constant of beta = 0.9 +/- 0.1 A-1, suggesting that tunneling is the mechanism of electron transport in the peptides. The conductance of the peptides is sensitive to the solution pH, due to the protonation/deprotonation of the amine and carboxyl groups of the peptides, which provides titration measurements based on single-molecule conductance.

  DOI：

  10.1021/ja049469a

文献信息

• Conductance Titration of Single-Peptide Molecules
  作者：Xiao、Xu、Tao

  DOI：10.1021/ja049469a

  日期：2004.5.1

  We have measured the conductance of single peptides covalently bonded to two Au electrodes via S-Au bonds by repeatedly forming a large number of molecular junctions. The conductance decreases exponentially with the peptide length, with a decay constant of beta = 0.9 +/- 0.1 A-1, suggesting that tunneling is the mechanism of electron transport in the peptides. The conductance of the peptides is sensitive to the solution pH, due to the protonation/deprotonation of the amine and carboxyl groups of the peptides, which provides titration measurements based on single-molecule conductance.