7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one;(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 石蒜科生物碱
• 英文名称: 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one;(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
• 化学式: C32H31Cl2N3O5
• 分子量: 608.5
• InChiKey: ZEGQLQKTHAQSRW-XPSHAMGMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.95
• 重原子数：
  42
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• CRANIAL DELIVERY OF PHARMACEUTICALS
  申请人：Glia LLC

  公开号：EP2968368A2

  公开（公告）日：2016-01-20
• [EN] CRANIAL DELIVERY OF PHARMACEUTICALS<br/>[FR] ADMINISTRATION CRÂNIENNE DE SUBSTANCES PHARMACEUTIQUES
  申请人：GLIA LLC

  公开号：WO2014152385A2

  公开（公告）日：2014-09-25

  A method for rapid delivery of an active compound to innervate a cranial nerve of a subject. Also provided is a method for treating a disease or condition by topically applying a pharmaceutical composition to the face excluding the palpebral part of the eye, in an amount effective for treating the disease or condition.