(1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid;4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid;4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
• 化学式: C42H60N2O16
• 分子量: 848.9
• InChiKey: DRFYGFFLFZWEOF-POBCMLFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.47
• 重原子数：
  60
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  304
• 氢给体数：
  11
• 氢受体数：
  18

文献信息

• CRANIAL DELIVERY OF PHARMACEUTICALS
  申请人：Glia LLC

  公开号：EP2968368A2

  公开（公告）日：2016-01-20
• [EN] CRANIAL DELIVERY OF PHARMACEUTICALS<br/>[FR] ADMINISTRATION CRÂNIENNE DE SUBSTANCES PHARMACEUTIQUES
  申请人：GLIA LLC

  公开号：WO2014152385A2

  公开（公告）日：2014-09-25

  A method for rapid delivery of an active compound to innervate a cranial nerve of a subject. Also provided is a method for treating a disease or condition by topically applying a pharmaceutical composition to the face excluding the palpebral part of the eye, in an amount effective for treating the disease or condition.