(6aR,1aR,11bS)-methyl 6a-(hydroxymethyl)-4,4,11b-trimethyl-7-oxo-2,3,4,4a,5,6,6a,7,8,11,11a,11b-dodecahydro-1H-cyclohepta[a]naphthalene-9-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (6aR,1aR,11bS)-methyl 6a-(hydroxymethyl)-4,4,11b-trimethyl-7-oxo-2,3,4,4a,5,6,6a,7,8,11,11a,11b-dodecahydro-1H-cyclohepta[a]naphthalene-9-carboxylate
• 英文别名: methyl 6a-(hydroxymethyl)-4,4,11b-trimethyl-7-oxo-2,3,4a,5,6,8,11,11a-octahydro-1H-cyclohepta[a]naphthalene-9-carboxylate
• 化学式: C₂₁H₃₂O₄
• 分子量: 348.483
• InChiKey: NPAZPPMBDKQQTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-methyl 2-(cyanomethyl)-4-((1R,2R,8aS)-5,5,8a-trimethyl octahydro-1H-spiro[naphthalene-2,2'-oxiran]-1-yl)but-2-enoate 在 二氯二茂钛 、 锌 、 sodium dihydrogenphosphate 作用下， 以 四氢呋喃 为溶剂， 反应 12.5h， 以60%的产率得到(6aR,1aR,11bS)-methyl 6a-(hydroxymethyl)-4,4,11b-trimethyl-7-oxo-2,3,4,4a,5,6,6a,7,8,11,11a,11b-dodecahydro-1H-cyclohepta[a]naphthalene-9-carboxylate
  参考文献：
  名称：

  GLUCAGON-LIKE PEPTIDE 1 (GLP-1) RECEPTOR MODULATORS AND USES THEREOF IN REGULATING BLOOD GLUCOSE LEVELS

  摘要：

  本公开提供了新型胰高血糖素样肽-1（GLP-1）受体调节剂，例如式（I）或（II）的化合物，以及其药学上可接受的盐。本公开还提供了涉及GLP-1受体调节剂用于调节血糖水平和/或治疗糖尿病的药物组合物、试剂盒和用途。例如，通过调节由GLP-1受体介导的内源性信号通路。

  公开号：

  US20140350100A1

文献信息

• [EN] GLUCAGON-LIKE PEPTIDE 1 (GLP-1) RECEPTOR MODULATORS AND USES THEREOF IN REGULATING BLOOD GLUCOSE LEVELS<br/>[FR] MODULATEURS DU RÉCEPTEUR DU GLUCAGON-LIKE PEPTIDE 1 (GLP-1) ET LEURS UTILISATIONS DANS LA RÉGULATION DES TAUX DE GLYCÉMIE
  申请人：ACADEMIA SINICA

  公开号：WO2014193832A2

  公开（公告）日：2014-12-04

  The present disclosure provides novel glucagon-like peptide-1 (GLP-1) receptor modulators such as compounds of Formula (I) or (II), and pharmaceutically acceptable salts thereof. The present disclosure also provides pharmaceutical compositions, kits, and uses that involve the GLP-1 receptor modulators for regulating blood glucose levels and/or treating diabetes via, e.g., modulating the endogenous signaling pathways mediated by the GLP-1 receptor.
• [EN] SYNTHESIS OF GALANAL COMPOUNDS AND ANALOGUES THEREOF<br/>[FR] SYNTHÈSE DE COMPOSÉS DE GALANAL ET LEURS ANALOGUES
  申请人：ACADEMIA SINICA

  公开号：WO2014193837A1

  公开（公告）日：2014-12-04

  The present disclosure provides methods of preparing glucagon-like peptide-1 (GLP-1) receptor modulators, such as compounds of Formula (II) or (VI), or intermediates thereof. The compounds that may be prepared by the described methods are useful for regulating blood glucose levels and/or treating a disease mediated by a GLP-1 receptor (e.g.diabetes).