[(2R,3S,4R,5R)-5-[(3-amino-1-methyl-4-oxopyrimido[4,5-c]pyridazin-5-yl)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3S,4R,5R)-5-[(3-amino-1-methyl-4-oxopyrimido[4,5-c]pyridazin-5-yl)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C₁₂H₁₇N₆O₈P
• 分子量: 404.27
• InChiKey: KSTINLBMIDYSAF-HPWYLLNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  213
• 氢给体数：
  6
• 氢受体数：
  13

文献信息

• Compositions and methods for preserving donated blood
  申请人：RYTHRX THERAPEUTICS, LLC

  公开号：US10117428B2

  公开（公告）日：2018-11-06

  Blood and platelet storage and rejuvenating compositions that include triciribine, triciribine metabolites, triciribine analogs, and mixtures of the same are disclosed. Such compositions can be useful in methods for treating (e.g., storing and rejuvenating) red blood cells and platelets.

  本发明公开了包括曲克瑞滨、曲克瑞滨代谢物、曲克瑞滨类似物及其混合物的血液和血小板储存与再生组合物。这种组合物可用于治疗（如储存和恢复活力）红细胞和血小板的方法。
• Compositions and methods for preserving red blood cells and platelets
  申请人：RYTHRX THERAPEUTICS, LLC

  公开号：US10426160B2

  公开（公告）日：2019-10-01

  Blood and platelet storage and rejuvenating compositions that include triciribine, triciribine metabolites, triciribine analogs, and mixtures of the same are disclosed. Such compositions can be useful in methods for treating (e.g., storing and rejuvenating) red blood cells and platelets.

  本发明公开了包括曲克瑞滨、曲克瑞滨代谢物、曲克瑞滨类似物及其混合物的血液和血小板储存与再生组合物。此类组合物可用于治疗（如储存和恢复活力）红细胞和血小板的方法。
• COMPOSITIONS AND METHODS FOR PRESERVING DONATED BLOOD
  申请人：RYTHRX THERAPEUTICS, LLC

  公开号：US20160157478A1

  公开（公告）日：2016-06-09

  Blood and platelet storage and rejuvenating compositions that include triciribine, triciribine metabolites, triciribine analogs, and mixtures of the same are disclosed. Such compositions can be useful in methods for treating (e.g., storing and rejuvenating) red blood cells and platelets.
• COMPOSITIONS AND METHODS FOR PRESERVING RED BLOOD CELLS AND PLATELETS
  申请人：RYTHRX THERAPEUTICS, LLC

  公开号：US20180360022A1

  公开（公告）日：2018-12-20

  Blood and platelet storage and rejuvenating compositions that include triciribine, triciribine metabolites, triciribine analogs, and mixtures of the same are disclosed. Such compositions can be useful in methods for treating (e.g., storing and rejuvenating) red blood cells and platelets.