[(2R,3S,4R,5R)-5-amino-1,2,4-trihydroxy-6-oxohexan-3-yl] dihydrogen phosphate | 109515-01-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3S,4R,5R)-5-amino-1,2,4-trihydroxy-6-oxohexan-3-yl] dihydrogen phosphate
• CAS: 109515-01-7
• 化学式: C₆H₁₄NO₈P
• 分子量: 259.15
• InChiKey: GAKVBLIQIVXARX-SLPGGIOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.1
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  171
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
  申请人：Corixa Corporation

  公开号：US20030199460A1

  公开（公告）日：2003-10-23

  Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.

  描述和声明了一种氨基糖胺磷酸酯（AGP）化合物，这些化合物是辅助剂和免疫效应物质。这些化合物具有一个2-脱氧-2-氨基葡萄糖与一个氨基烷基（非糖部分）基团在糖苷键中连接的结构。这些化合物在葡萄糖氨基糖环的4或6碳上磷酸化，并包括三个3-烷酰氧烷酰残基。这些化合物增强了免疫动物中的抗体产生，同时也刺激细胞因子的产生并激活巨噬细胞。还公开了将这些化合物作为辅助剂和免疫效应物质使用的组合物和方法。
• [EN] AMINOALKYL GLUCOSAMINE PHOSPHATE COMPOUNDS AND THEIR USE AS ADJUVANTS AND IMMUNOEFFECTORS<br/>[FR] COMPOSES D'AMINOALKYLE GLUCOSAMINE PHOSPHATES ET LEUR UTILISATION COMME ADJUVANTS ET IMMUNOEFFECTEURS
  申请人：CORIXA CORPORATION

  公开号：WO1998050399A1

  公开（公告）日：1998-11-12

  (EN) Aminoalkyl glucosamine phosphate compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosamine ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.(FR) La présente invention concerne des composés d'aminoalkyle glucosamine phosphates qui sont des adjuvants et des immunoeffecteurs. Ces composés ont un 2-désoxy-2-aminoglucose en liaison glucidique avec un groupe aminoalkyle (aglycon). Ces composés sont phosphorylés au niveau du carbone 4 ou 6 sur le noyau de glucoseamine et comprennent trois résidus 3-alcanoyloxyalcanoyle. Les composés augmentent la production d'anticorps chez des animaux immunisés, stimulent la production de cytokine et activent des macrophages. La présente invention concerne également des procédés d'utilisation de ces composés comme adjuvants et immunoeffecteurs.

  (中文) 描述并声明了一种作为辅助剂和免疫效应物质的氨基糖磷酸化合物。这些化合物在糖苷键上具有2-去氧-2-氨基葡萄糖和氨基烷基（脱糖基）基团。化合物在葡萄糖胺环上的4或6碳处磷酸化，并包括三个3-烷酰氧基烷酰基残基。这些化合物增强了免疫动物中的抗体产生，同时刺激细胞因子的产生和激活巨噬细胞。还公开了使用这些化合物作为辅助剂和免疫效应物质的方法。
• MENINGOCOCCUS SEROGROUP X CONJUGATE
  申请人：NOVARTIS AG

  公开号：US20150104479A1

  公开（公告）日：2015-04-16

  The invention provides a conjugate of a Neisseria meningitidis serogroup X capsular polysaccharide and a carrier molecule. The conjugate is typically made by (a) oxidising a primary hydroxyl group in the capsular polysaccharide, to give an oxidised polysaccharide with an aldehyde group; and (b) coupling the oxidised polysaccharide to a carrier molecule via the aldehyde group, thereby giving the conjugate. The conjugate may be part of an immunogenic composition. This composition may comprise one or more further antigens, particularly capsular polysaccharides from serogroups A, W135, C and Y and conjugated forms thereof. The composition may be in an aqueous formulation. The composition is useful as a vaccine, e.g. for raising an immune response in a mammal. The invention also provides processes for making the conjugate.

  该发明提供了一种Neisseria meningitidis X群胶囊多糖和载体分子的结合物。通常通过以下步骤制备该结合物：（a）氧化胶囊多糖中的主要羟基，生成带有醛基的氧化多糖；（b）通过醛基将氧化多糖与载体分子偶联，从而生成结合物。该结合物可以是免疫原性组合物的一部分。该组合物可以包括一个或多个进一步的抗原，特别是A、W135、C和Y血清群的胶囊多糖及其共轭形式。该组合物可以是水性制剂。该组合物可用作疫苗，例如，用于提高哺乳动物的免疫反应。该发明还提供了制备该结合物的方法。
• [EN] MENINGOCOCCUS SEROGROUP X CONJUGATE<br/>[FR] CONJUGUÉ DE SÉROGROUPE X DE MÉNINGOCOQUE
  申请人：NOVARTIS AG

  公开号：WO2013174832A1

  公开（公告）日：2013-11-28

  The invention provides a conjugate of a Neisseria meningitidis serogroup X capsular polysaccharide and a carrier molecule. The conjugate is typically made by (a) oxidising a primary hydroxyl group in the capsular polysaccharide, to give an oxidised polysaccharide with an aldehyde group; and (b) coupling the oxidised polysaccharide to a carrier molecule via the aldehyde group, thereby giving the conjugate. The conjugate may be part of an immunogenic composition. This composition may comprise one or more further antigens, particularly capsular polysaccharides from serogroups A, W135, C and Y and conjugated forms thereof. The composition may be in an aqueous formulation. The composition is useful as a vaccine, e.g. for raising an immune response in a mammal. The invention also provides processes for making the conjugate.

  本发明提供了一种Neisseria meningitidis X群胶囊多糖和载体分子的结合物。该结合物通常是通过以下步骤制备的：（a）氧化胶囊多糖中的主要羟基，以得到具有醛基的氧化多糖；（b）通过醛基将氧化多糖与载体分子偶联，从而得到结合物。该结合物可以是免疫原组合物的一部分。该组合物可以包括一个或多个进一步的抗原，特别是A、W135、C和Y群的胶囊多糖及其结合形式。该组合物可以是水性配方。该组合物可用作疫苗，例如用于提高哺乳动物的免疫反应。本发明还提供了制备结合物的方法。
• Modified hepatitis C virus (HCV) NS3 for medical treatment
  申请人：INNOGENETICS N.V.

  公开号：EP1481985A1

  公开（公告）日：2004-12-01

  The present invention relates to peptides or polypeptides comprising an HCV NS3 protein or a part thereof or a derivative of said peptide or polypeptide, HCV NS3 protein or part thereof wherein at least one cysteine is irreversibly modified. These modified HCV NS3 proteins have advantageous properties both for diagnostic and therapeutic/prophylactic applications.

  本发明涉及由 HCV NS3 蛋白或其一部分或上述肽或多肽、HCV NS3 蛋白或其一部分的衍生物组成的肽或多肽，其中至少有一个半胱氨酸被不可逆地修饰。这些经过修饰的 HCV NS3 蛋白在诊断和治疗/预防应用方面都具有优势特性。