Rotraxate hydrochloride | 82085-94-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Rotraxate hydrochloride
• 英文别名: 3-[4-[4-(aminomethyl)cyclohexanecarbonyl]phenyl]propanoic acid;hydrochloride
• CAS: 82085-94-7
• 化学式: C17H24ClNO3
• 分子量: 325.8
• InChiKey: SQPDKJPOCJNLSJ-UHFFFAOYSA-N

物化性质

• 熔点：
  245° (dec) (Takeshita, 1985); mp 221-227° (Takeshita, 1983)

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  80.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 3-propionate hydrochloride 以88的产率得到Rotraxate hydrochloride
  参考文献：
  名称：

  Chem. Pharm. Bull. 1985, 11, 5059-5061

  摘要：

  DOI：

文献信息

• PHOTOREACTIVE POLYSACCHARIDE, PHOTOCROSSLINKED POLYSACCHARIDE PRODUCT AND METHOD OF MAKING SAME AND MEDICAL MATERIALS MADE FROM THE CROSSLINKED POLYSACCHARIDE
  申请人：Sato Tomoya

  公开号：US20060057098A1

  公开（公告）日：2006-03-16

  A photoreactive polysaccharide which comprises a polysaccharide bound to a glycidyl ester via a covalent bond, a photocrosslinked-polysaccharide prepared by using the photoreactive polysaccharide, and medical products comprising the photocrosslinked-polysaccharide.

  一种光反应性多糖，包括通过共价键与环氧丙烯酯结合的多糖，使用该光反应性多糖制备的光交联多糖，以及包含光交联多糖的医疗产品。
• Sustained release preparation
  申请人：TEIJIN LIMITED

  公开号：EP0187703A2

  公开（公告）日：1986-07-16

  A sustained release preparation comprising: (a) chitin, chitosan, or a mixture thereof (b) anionic polymer compounds such as those having a carboxyl group, a sulfonic acid group, or a group capable of providing the same, and (c) pharmaceutically active agents. This sustained release preparation can provide the desired sustained-release or dissolution of the pharmaceutically active agents in human organs irrespective of the acidity (i.e., pH conditions) therein.

  一种缓释制剂，包括：(a) 甲壳素、壳聚糖或它们的混合物；(b) 阴离子聚合物化合物，如具有羧基、磺酸基或能提供相同羧基、磺酸基的化合物；(c) 药物活性剂。 这种缓释制剂能在人体器官中提供所需的药物活性剂的缓释或溶解，而不受其中酸度（即 pH 值条件）的影响。
• Photoreactive polysaccharide. photocrosslinked polysaccharide products, the method of making them and medical materials made therefrom
  申请人：SEIKAGAKU CORPORATION

  公开号：EP2287205A2

  公开（公告）日：2011-02-23

  The present invention is directed to a photoreactive polysaccharide which comprises hyaluronic acid covalently bonded to a glycidyl ester of the photoreactive compound represented by the formula (I): wherein R1-CO- represents a residue of a photoreactive compound having the carboxyl group(s) identified, and an unsaturated carbon double bond, selected from the group consisting of cinnamic acid, thiopheneacrylic acid, cinnamylideneacetic acid and sorbic acid, a photocrosslinked polysaccharide produced by crosslinking the above-mentioned polysaccharide by light irradiation, as well as a medical product comprising the same. Preferably the medical product is an anti-adhesive agent for a substrate for sustained drug release or a substrate for culturing cells.

  本发明涉及一种光活性多糖，它包括与式 (I) 所代表的光活性化合物的缩水甘油酯共价键合的透明质酸： 其中 R1-CO- 代表光活性化合物的残基，该化合物具有所确定的羧基和不饱和碳双键，该化合物可从肉桂酸、噻吩丙烯酸、亚肉桂基乙酸和山梨酸组成的组中选择；通过光照射交联上述多糖而产生的光交联多糖；以及包含上述多糖的医疗产品。该医疗产品最好是用于药物持续释放基质或细胞培养基质的抗粘剂。
• Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical composition, containing at least one of these compounds
  申请人：TEIJIN LIMITED

  公开号：EP0044541B1

  公开（公告）日：1983-09-21
• Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof
  申请人：SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION)

  公开号：EP0554898B1

  公开（公告）日：1997-05-07