1-(2-amino-6-methoxyphenyl)ethan-1-one hydrochloride | 1803567-10-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-amino-6-methoxyphenyl)ethan-1-one hydrochloride
• 英文别名: 1-(2-Amino-6-methoxyphenyl)ethan-1-one hydrochloride；1-(2-amino-6-methoxyphenyl)ethanone;hydrochloride
• CAS: 1803567-10-3
• 化学式: C₉H₁₁NO₂*ClH
• mdl: MFCD28145320
• 分子量: 201.653
• InChiKey: MXFGMXDSHAETIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.19
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  sodium dicyanamide 、 1-(2-amino-6-methoxyphenyl)ethan-1-one hydrochloride 以 乙醇 为溶剂， 以46 %的产率得到N-(5-methoxy-4-methylquinazolin-2-yl)cyanamide
  参考文献：
  名称：

  [EN] COMPOUNDS
  [FR] COMPOSÉS

  摘要：

  Disclosed are compounds of the formula (I), or a tautomeric form thereof, or a pharmaceutically acceptable salt or N-oxide thereof: (I) wherein R1, R2, R3, R4, R5, n, m, and x are as defined herein. Compounds of the invention may be suitable for use in treating diseases/conditions which are associated with PTC mutations. Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in treating conditions or disorders which are associated with PTC mutations in a subject.

  公开号：

  WO2024003535A2
• 作为产物：
  描述：

  2-溴-3-甲氧基苯胺 、 (1-butoxyvinyl)tributylstannane 在 四(三苯基膦)钯 、 盐酸 作用下， 以 甲苯 、 1,4-二氧六环 为溶剂， 以15 %的产率得到1-(2-amino-6-methoxyphenyl)ethan-1-one hydrochloride
  参考文献：
  名称：

  [EN] COMPOUNDS
  [FR] COMPOSÉS

  摘要：

  Disclosed are compounds of the formula (I), or a tautomeric form thereof, or a pharmaceutically acceptable salt or N-oxide thereof: (I) wherein R1, R2, R3, R4, R5, n, m, and x are as defined herein. Compounds of the invention may be suitable for use in treating diseases/conditions which are associated with PTC mutations. Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in treating conditions or disorders which are associated with PTC mutations in a subject.

  公开号：

  WO2024003535A2

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSÉS
  申请人：[en]UNIVERSITY OF DUNDEE

  公开号：WO2024003535A2

  公开（公告）日：2024-01-04

  Disclosed are compounds of the formula (I), or a tautomeric form thereof, or a pharmaceutically acceptable salt or N-oxide thereof: (I) wherein R1, R2, R3, R4, R5, n, m, and x are as defined herein. Compounds of the invention may be suitable for use in treating diseases/conditions which are associated with PTC mutations. Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in treating conditions or disorders which are associated with PTC mutations in a subject.