Adiposin 2 | 83764-12-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Adiposin 2
• 英文别名: (2R,3R,4R,5R)-4-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4S,5S)-3,4-dihydroxy-6-(hydroxymethyl)-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanal
• CAS: 83764-12-9
• 化学式: C₂₅H₄₃NO₁₉
• 分子量: 661.6
• InChiKey: SWCIZDWVIVXZIC-WJCGAKIDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9.3
• 重原子数：
  45
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  349
• 氢给体数：
  15
• 氢受体数：
  20

文献信息

• Treatment of rumen acidosis with alpha-amylase inhibitors
  申请人：Banks Joseph Bernard

  公开号：US20050233983A1

  公开（公告）日：2005-10-20

  The invention described herein relates to: the use of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in the manufacture of a composition for the treatment of rumen acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase to a ruminant; a formulation suitable for the treatment of rumen acidosis in an animal which comprises an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial α-amylase and/or α-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial α-amylase and/or α-glucosidase; a compound of the formula I: or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial α-amylase and/or α-glucosidase useful for the treatment of acidosis in a ruminant.

  本发明涉及细菌α-淀粉酶和/或α-葡萄糖苷酶的有效抑制剂在制造治疗瘤胃酸中毒的组合物中的用途； 一种治疗瘤胃酸中毒的方法，包括向反刍动物施用有效量的细菌α-淀粉酶和/或α-葡萄糖苷酶的有效抑制剂；一种适用于治疗动物瘤胃酸中毒的制剂，该制剂由细菌α-淀粉酶和/或α-葡萄糖苷酶的有效抑制剂与根据预期给药途径和标准制药/兽医/饲养实践选择的合适赋形剂、稀释剂或载体混合组成；用于鉴定治疗反刍动物酸中毒的细菌 α-淀粉酶和/或 α-葡萄糖苷酶的合适抑制剂的筛选方法； 改善反刍动物牛奶质量和/或数量的工艺，该工艺包括用有效量的细菌 α-淀粉酶和/或 α-葡萄糖苷酶抑制剂处理反刍动物； 式 I 的化合物： 或其兽医可接受的盐、溶液剂（包括水合物）或原药；以及制造用于治疗反刍动物酸中毒的细菌α-淀粉酶和/或α-葡萄糖苷酶有效抑制剂的工艺。