7-Deoxypactamycin | 11005-94-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-Deoxypactamycin
• 英文别名: [(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-(dimethylcarbamoylamino)-3-ethyl-1,2-dihydroxy-2-methylcyclopentyl]methyl 2-hydroxy-6-methylbenzoate
• CAS: 11005-94-0；104820-96-4
• 化学式: C₂₈H₃₈N₄O₇
• 分子量: 542.6
• InChiKey: ZDHIGMAZJWYGPX-YONDKBSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• PACTAMYCIN ANALOGS AND METHODS OF MAKING THEREOF
  申请人：Oregon State University

  公开号：US20150183730A1

  公开（公告）日：2015-07-02

  This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin. The present disclosure also relates to the use of the pactamycin biosynthetic genes located within the identified gene cluster for drug design and development purposes, including the development of pactamycin analogs that are more efficacious and less toxic. Also provided are drugs and antibiotics so produced, as well as methods of their use.
• US9452976B2
  申请人：——

  公开号：US9452976B2

  公开（公告）日：2016-09-27