3-[4'-(4''-chorophenyl)-6'-(3''-chlorophenyl)pyrimidin-2'-yl]-2-phenylthiazolidin-4-one | 1195977-49-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-[4'-(4''-chorophenyl)-6'-(3''-chlorophenyl)pyrimidin-2'-yl]-2-phenylthiazolidin-4-one
• 英文别名: 3-[4-(3-Chlorophenyl)-6-(4-chlorophenyl)pyrimidin-2-yl]-2-phenyl-1,3-thiazolidin-4-one
• CAS: 1195977-49-1
• 化学式: C₂₅H₁₇Cl₂N₃OS
• 分子量: 478.401
• InChiKey: MPXSTKJBXOTJRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  71.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(3-chlorophenyl)-6-(4-chlorophenyl) pyrimidin-2-amine 、 苯甲醛 、 巯基乙酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以60%的产率得到3-[4'-(4''-chorophenyl)-6'-(3''-chlorophenyl)pyrimidin-2'-yl]-2-phenylthiazolidin-4-one
  参考文献：
  名称：

  Synthesis and spectral analysis of novel 3-(4,6-diarylpyrimidin-2-yl)-2-phenylthiazolidin-4-ones

  摘要：

  Novel 3-(4,6-diarylpyrimidin-2-yl)-2-phenylthiazolidin-4-ones are synthesized by the multicomponent cyclocondensation reaction of the appropriate 2-amino-4,6-diarylpyrimidines, benzaldehyde, and thioglycolic acid catalyzed by dicyclohexylcarbodiimide. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, H-1 and (13) NMR spectroscopic data.

  DOI：

  10.1007/s10593-010-0462-9

文献信息

• Synthesis and spectral analysis of novel 3-(4,6-diarylpyrimidin-2-yl)-2-phenylthiazolidin-4-ones
  作者：M. Gopalakrishnan、J. Thanusu、V. Kanagarajan

  DOI：10.1007/s10593-010-0462-9

  日期：2009.12

  Novel 3-(4,6-diarylpyrimidin-2-yl)-2-phenylthiazolidin-4-ones are synthesized by the multicomponent cyclocondensation reaction of the appropriate 2-amino-4,6-diarylpyrimidines, benzaldehyde, and thioglycolic acid catalyzed by dicyclohexylcarbodiimide. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, H-1 and (13) NMR spectroscopic data.