7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-(4-methoxybenzylamino)-4H-chromen-4-one | 1094471-16-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-(4-methoxybenzylamino)-4H-chromen-4-one
• 英文别名: 2-(4-Methoxy-3-phenylmethoxyphenyl)-5-[(4-methoxyphenyl)methylamino]-7-phenylmethoxychromen-4-one
• CAS: 1094471-16-5
• 化学式: C₃₈H₃₃NO₆
• 分子量: 599.683
• InChiKey: MTDDDBTVJPVMFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  45
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  75.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-(4-methoxybenzylamino)-4H-chromen-4-one 在 1% Pd/C 、 氢气 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以60%的产率得到7-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-5-(4-methoxybenzylamino)-4H-chromen-4-one
  参考文献：
  名称：

  A convenient microwave-assisted 5-amination of flavones

  摘要：

  A few examples of 5-aminoflavones' syntheses exist in the literature and for those, which are described, the amino group is introduced before the formation of the flavone skeleton. We describe here an efficient method, which permits the access to 5-aminoflavones by a simple procedure Using all SNAr amination under microwaves irradiation. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.09.043
• 作为产物：
  描述：

  7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-trifluoromethanesulfonyloxy-4H-chromen-4-one 、 4-甲氧基苄胺 以 N-甲基吡咯烷酮 为溶剂， 反应 0.25h， 以92%的产率得到7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-(4-methoxybenzylamino)-4H-chromen-4-one
  参考文献：
  名称：

  A convenient microwave-assisted 5-amination of flavones

  摘要：

  A few examples of 5-aminoflavones' syntheses exist in the literature and for those, which are described, the amino group is introduced before the formation of the flavone skeleton. We describe here an efficient method, which permits the access to 5-aminoflavones by a simple procedure Using all SNAr amination under microwaves irradiation. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.09.043

文献信息

• A convenient microwave-assisted 5-amination of flavones
  作者：Cédric Lecoutey、Christine Fossey、Luc Demuynck、François Lefoulon、Frédéric Fabis、Sylvain Rault

  DOI：10.1016/j.tet.2008.09.043

  日期：2008.12

  A few examples of 5-aminoflavones' syntheses exist in the literature and for those, which are described, the amino group is introduced before the formation of the flavone skeleton. We describe here an efficient method, which permits the access to 5-aminoflavones by a simple procedure Using all SNAr amination under microwaves irradiation. (C) 2008 Elsevier Ltd. All rights reserved.