(E)-cyclododecene-1-carboxylic acid | 884-37-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (E)-cyclododecene-1-carboxylic acid
• 英文别名: (1E)-cyclododecene-1-carboxylic acid
• CAS: 884-37-7
• 化学式: C₁₃H₂₂O₂
• 分子量: 210.316
• InChiKey: AYRFSEXTGFEZKA-ZRDIBKRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-cyclododecene-1-carboxylic acid 在 吡啶 、 4-二甲氨基吡啶 、 草酰氯 、 偶氮二异丁腈 、 三氯溴甲烷 作用下， 生成 (E)-1-bromocyclododecene
  参考文献：
  名称：

  Regioselective conversion of cycloalkanones to vinyl bromides with 1,2-functionality transposition. A general stratagem

  摘要：

  Cyclic beta-keto esters, available by regioselective acylation of cycloalkanone enolates, are rapidly transformed to alpha,beta-unsaturated acids. This functionality transposition allows the derived 3-hydroxy-4-methylthiazole-2-(3H)-thione derivatives to serve as precursors to synthetically useful vinyl bromides. The process involves heating the hydroxamate ester with AIBN in bromotrichloromethane solution. Alkylative and ring contractive variants of the methodology are highlighted. The short sequence makes available precursors to vinyl anions that are not otherwise conveniently accessible.

  DOI：

  10.1021/jo00021a044
• 作为产物：
  描述：

  二氧化碳 、 cyclododec-1-en-1-yl trifluoromethanesulfonate 在 bis(2-phenylpyridinato)(2,2'-bipyridine)iridium(III) hexafluorophosphate 、 bis(3,5-bis(trifluoromethyl)phenyl)(2',4',6'-triisopropylbiphenyl-2-yl)phosphine 、 四丁基溴化铵 、 palladium diacetate 、 caesium carbonate 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 2.0h， 以78%的产率得到
  参考文献：
  名称：

  钯催化光催化氧化芳基和烯基三氟甲磺酸酯的羧基

  摘要：

  通过使用Pd和光氧化还原催化剂的组合，可见光驱动的芳基和烯基三氟甲磺酸酯与CO 2的羧化反应。该反应在温和的条件下进行，可用于多种底物，包括无环烯基三氟甲磺酸酯。

  DOI：

  10.1021/acs.orglett.9b01340

文献信息

• POLYPROPYLENE RESIN MOLDED ARTICLE
  申请人：New Japan Chemical Co., Ltd.

  公开号：EP2392458A2

  公开（公告）日：2011-12-07

  The present invention provides a polypropylene-based resin molded article having an excellent balance of rigidity, heat resistance, and impact resistance, and, in particular, having high impact strength; a method for producing the polypropylene-based resin molded article; and a method for improving the impact resistance of a polypropylene-based resin molded article. The polypropylene-based resin molded article comprising a layered structure including layers A and B comprising a polypropylene-based resin, one of the layers A and B having a polypropylene chain orientation different from that of the other layer; and each of the layers A and B having a maximum absolute value of birefringence of 0.005 or more, the birefringences of the layers A and B being different from each other, one being positive and the other being negative.

  本发明提供了一种在刚性、耐热性和抗冲击性之间具有良好平衡，特别是具有高抗冲击强度的聚丙烯基树脂模塑品；一种生产聚丙烯基树脂模塑品的方法；以及一种提高聚丙烯基树脂模塑品抗冲击性的方法。 聚丙烯基树脂模塑品包括分层结构，包括由聚丙烯基树脂组成的层 A 和 B，层 A 和 B 中的一层具有与另一层不同的聚丙烯链取向；层 A 和 B 中的每一层具有 0.005 或更大的双折射最大绝对值，层 A 和 B 的双折射彼此不同，一层为正，另一层为负。
• Palladium-Catalyzed Visible-Light-Driven Carboxylation of Aryl and Alkenyl Triflates by Using Photoredox Catalysts
  作者：Katsuya Shimomaki、Tomoya Nakajima、Joaquim Caner、Naoyuki Toriumi、Nobuharu Iwasawa

  DOI：10.1021/acs.orglett.9b01340

  日期：2019.6.21

  A visible-light-driven carboxylation of aryl and alkenyl triflates with CO2 is developed by using a combination of Pd and photoredox catalysts. This reaction proceeds under mild conditions and can be applied to a wide range of substrates including acyclic alkenyl triflates.

  通过使用Pd和光氧化还原催化剂的组合，可见光驱动的芳基和烯基三氟甲磺酸酯与CO 2的羧化反应。该反应在温和的条件下进行，可用于多种底物，包括无环烯基三氟甲磺酸酯。
• Regioselective conversion of cycloalkanones to vinyl bromides with 1,2-functionality transposition. A general stratagem
  作者：Leo A. Paquette、Karl Dahnke、Julien Doyon、Wei He、Kenetha Wyant、Dirk Friedrich

  DOI：10.1021/jo00021a044

  日期：1991.10

  Cyclic beta-keto esters, available by regioselective acylation of cycloalkanone enolates, are rapidly transformed to alpha,beta-unsaturated acids. This functionality transposition allows the derived 3-hydroxy-4-methylthiazole-2-(3H)-thione derivatives to serve as precursors to synthetically useful vinyl bromides. The process involves heating the hydroxamate ester with AIBN in bromotrichloromethane solution. Alkylative and ring contractive variants of the methodology are highlighted. The short sequence makes available precursors to vinyl anions that are not otherwise conveniently accessible.