(2S,4S,5R,6R)-5-[acetyl-(2-azidoacetyl)amino]-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,4S,5R,6R)-5-[acetyl-(2-azidoacetyl)amino]-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• 化学式: C13H20N4O10
• 分子量: 392.32
• InChiKey: JCZHTIPIUYMXBP-FWADUHFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  199
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• Cyclopropenones and the Photochemical Generation of Cyclic Alkynes Therefrom
  申请人：Popik Vladimir V.

  公开号：US20100210854A1

  公开（公告）日：2010-08-19

  Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.

  环状炔烃（例如，二苯并环辛烯等）可以从环丙酮烯光化学地生成，如本文所披露的。这些环状炔烃可以与具有炔烃反应基团（例如，“点击”反应中的偶氮基团）的材料发生反应（例如，在原位）。在优选实施例中，环状炔烃的生成和反应可以在无催化剂（例如，Cu(I)）的情况下进行。这些反应可以用于例如，用于选择性标记通过含有偶氮基团表面单糖代谢修饰的活细胞，或用于光导向表面图案。
• ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS
  申请人：UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

  公开号：US20160159732A1

  公开（公告）日：2016-06-09

  1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.

  1,3-双极功能化合物（例如，叠氮基功能化合物）可以与某些炔烃在环化反应中发生反应，形成杂环化合物。还公开了有用的炔烃（例如，受应力、环状炔烃）和制备这种炔烃的方法。1,3-双极功能化合物与炔烃的反应可用于各种应用，包括将生物分子固定在基底上。
• [EN] IMPROVED METHODS OF IMAGING WITH Ga-68 LABELED MOLECULES<br/>[FR] PROCÉDÉS AMÉLIORÉS D'IMAGERIE AVEC DES MOLÉCULES MARQUÉES AU GA-68
  申请人：IMMUNOMEDICS INC

  公开号：WO2017007807A1

  公开（公告）日：2017-01-12

  The present application discloses compositions and methods of use of 68Ga labeled molecules. Preferably, the 68Ga is attached to a peptide targetable construct and is used in a pretargeting technique with a bispecific antibody (bsAb). The bsAb comprises at least one binding site for a disease-associated antigen, such as a tumor-associated antigen, and at least one binding site for a hapten on the targetable construct. Exemplary haptens include In-DTPA and HSG. More preferably, the bsAb is administered about 24-30 hours before the targetable construct, and detection by PET imaging occurs about 1-2 hours after the targetable construct is administered. The methods and compositions are suitable for detection, diagnosis and/or imaging of various diseases, such as cancer or infectious disease.

  本申请公开了68Ga标记分子的组成和使用方法。优选地，68Ga附着在可靶向的肽构造物上，并与双特异性抗体（bsAb）一起用于一种预靶向技术。该bsAb至少包括一个与疾病相关抗原（如肿瘤相关抗原）结合的结合位点，以及一个与可靶向构造物上的半抗原结合的结合位点。示例半抗原包括In-DTPA和HSG。更优选地，bsAb在可靶向构造物之前约24-30小时给予，并在可靶向构造物给予后约1-2小时进行PET成像检测。这些方法和组成适用于检测、诊断和/或成像各种疾病，如癌症或传染病。
• RADIOSENSITIVITY OF FLUOROPHORES AND USE OF RADIOPROTECTIVE AGENTS FOR DUAL-MODALITY IMAGING
  申请人：Immunomedics, Inc.

  公开号：US20160199524A1

  公开（公告）日：2016-07-14

  The present application discloses compositions and methods of use of dual-labeled molecules comprising a fluorescent probe and a radionuclide. The labeled molecules are of use for detection, imaging and/or diagnosis of diseased tissues, such as tumors. In preferred embodiments, the dual-labeled molecules are of use in pre-operative and/or intraoperative imaging, for example to detect margins of malignant tissues to facilitate surgical resectioning. In more preferred embodiments, a radioprotective agent such as an oxygen radical scavenger is used to decrease radiolysis of the fluorescent signal. The labeled molecules bind to a disease-associated antigen, such as a tumor-associated antigen. Exemplary molecules include antibodies, antibody fragments, bispecific antibodies, targetable constructs and targeting peptides, such as bombesin analogues.

  本申请公开了一种包含荧光探针和放射性核素的双标记分子的组合物及其使用方法。这些标记分子可用于检测、成像和/或诊断疾病组织，如肿瘤。在优选实施例中，双标记分子可用于术前和/或术中成像，例如检测恶性组织的边缘以便于手术切除。在更优选的实施例中，使用放射保护剂，如氧自由基清除剂，以减少荧光信号的辐解。标记分子结合到与疾病相关的抗原，如肿瘤相关抗原。示例分子包括抗体、抗体片段、双特异性抗体、可靶向构建物和靶向肽，如炸弹素类似物。
• [EN] PRO-DRUG FORM (P2PDOX) OF THE HIGHLY POTENT 2-PYRROLINODOXORUBICIN CONJUGATED TO ANTIBODIES FOR TARGETED THERAPY OF CANCER<br/>[FR] FORME DE PRO-MÉDICAMENT (P2PDOX) DE LA 2-PYRROLINODOXORUBICINE FORTEMENT PUISSANTE CONJUGUÉE À DES ANTICORPS POUR LA THÉRAPIE CIBLÉE DU CANCER
  申请人：IMMUNOMEDICS INC

  公开号：WO2014124227A1

  公开（公告）日：2014-08-14

  Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2- pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments thereof (ADCs), with targetable construct peptides or with other targeting molecules that are capable of delivering the P2PDox to a targeted cell, tissue or pathogen. Once delivered to the target cell, the ADC or peptide conjugate is internalized, a highly toxic 2-pyrrolinodoxorubicin (2- PDox) is released intracellularly. The P2PDox-peptide or ADC conjugates are of use to treat a wide variety of diseases, such as cancer, autoimmune disease or infectious disease.

  本发明涉及2-吡咯烷基多柔比星（P2PDox）的前药形式与抗体或其抗原结合片段（ADC）、可靶向构建肽或其他靶向分子的结合物的共轭物的方法、组合物和用途，这些结合物能够将P2PDox递送到目标细胞、组织或病原体。一旦递送到目标细胞，ADC或肽共轭物被内吞，高毒性的2-吡咯烷基多柔比星（2-PDox）在细胞内释放。P2PDox-肽或ADC共轭物可用于治疗各种疾病，如癌症、自身免疫性疾病或传染病。