摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

2-(4-Iodo-benzenesulfonyl)-1-(4-nitro-phenyl)-ethanone | 130189-00-3

中文名称
——
中文别名
——
英文名称
2-(4-Iodo-benzenesulfonyl)-1-(4-nitro-phenyl)-ethanone
英文别名
2-(4-Iodophenyl)sulfonyl-1-(4-nitrophenyl)ethanone
2-(4-Iodo-benzenesulfonyl)-1-(4-nitro-phenyl)-ethanone化学式
CAS
130189-00-3
化学式
C14H10INO5S
mdl
——
分子量
431.208
InChiKey
DLTFZXIPJPMVPC-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3
  • 重原子数:
    22
  • 可旋转键数:
    4
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.07
  • 拓扑面积:
    105
  • 氢给体数:
    0
  • 氢受体数:
    5

反应信息

  • 作为产物:
    描述:
    4-碘苯磺酰氯碳酸氢钠 、 sodium sulfite 作用下, 以 乙醇 为溶剂, 反应 0.5h, 生成 2-(4-Iodo-benzenesulfonyl)-1-(4-nitro-phenyl)-ethanone
    参考文献:
    名称:
    Rapid synthesis of sulfone derivatives as potential anti-infectious agents
    摘要:
    An original one-pot microwave reaction was developed for the synthesis of sulfone derivatives as new potent antimicrobial agents. This ecofriendly methodology conducted in 30 min led to desired products with good yields. The sulfones (4a and 4b) were obtained via the reaction of 3a with the corresponding halo-derivatives in the presence of sodium hydride.All compounds were tested for their antibacterial and antifungal activities against four bacterial strains (two gram positive, and two gram negative ones) and two yeasts. The disk diffusion method has shown an interesting antibacterial activity for seven compounds (3b-g and 4b) against Staphylococcus attreus. Among these seven compounds, five derivatives (3b-e and 3g) showed activity against Candida tropicalis. (c) 2007 Elsevier Masson SAS. All rights reserved.
    DOI:
    10.1016/j.ejmech.2006.12.015
点击查看最新优质反应信息

文献信息

  • Rapid synthesis of sulfone derivatives as potential anti-infectious agents
    作者:C. Curti、M. Laget、A. Ortiz Carle、A. Gellis、P. Vanelle
    DOI:10.1016/j.ejmech.2006.12.015
    日期:2007.6
    An original one-pot microwave reaction was developed for the synthesis of sulfone derivatives as new potent antimicrobial agents. This ecofriendly methodology conducted in 30 min led to desired products with good yields. The sulfones (4a and 4b) were obtained via the reaction of 3a with the corresponding halo-derivatives in the presence of sodium hydride.All compounds were tested for their antibacterial and antifungal activities against four bacterial strains (two gram positive, and two gram negative ones) and two yeasts. The disk diffusion method has shown an interesting antibacterial activity for seven compounds (3b-g and 4b) against Staphylococcus attreus. Among these seven compounds, five derivatives (3b-e and 3g) showed activity against Candida tropicalis. (c) 2007 Elsevier Masson SAS. All rights reserved.
查看更多