6-(4-(甲基磺酰基)苯基)吡啶-3-醇 | 1032825-20-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-(4-(甲基磺酰基)苯基)吡啶-3-醇
• 中文别名: 5-羟基-2-(4-甲基磺酰基苯基)吡啶
• 英文名称: 6-[4-(methylsulfonyl)phenyl]-3-pyridinol
• 英文别名: 6-(4-(Methylsulfonyl)phenyl)pyridin-3-ol；6-(4-methylsulfonylphenyl)pyridin-3-ol
• CAS: 1032825-20-9
• 化学式: C₁₂H₁₁NO₃S
• 分子量: 249.29
• InChiKey: PTUPRGVDEBLUCK-UHFFFAOYSA-N

物化性质

• 沸点：
  547.3±50.0 °C(Predicted)
• 密度：
  1.324±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933399090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 5-Hydroxy-2-(4-methylsulfonylphenyl)pyridine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 5-Hydroxy-2-(4-methylsulfonylphenyl)pyridine
CAS number: 1032825-20-9

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C12H11NO3S
Molecular weight: 249.3

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  6-(4-(甲基磺酰基)苯基)吡啶-3-醇 、 (1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methanol 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 gsk 1292263; 5-[[[1-(3-异丙基-1,2,4-噁二唑-5-基)-4-哌啶基]甲基]氧基]-2-[4-(甲磺酰基)苯基]吡啶
  参考文献：
  名称：

  BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS

  摘要：

  本发明涉及一种新型化合物，该化合物在治疗代谢性疾病，特别是Ⅱ型糖尿病及相关疾病方面具有用途，并且还涉及制备和使用这种化合物的方法。

  公开号：

  US20100029650A1
• 作为产物：
  描述：

  2-溴-5-羟基吡啶 、 4-（甲磺酰基）苯硼酸 在 四(三苯基膦)钯 sodium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 反应 18.0h， 以68%的产率得到6-(4-(甲基磺酰基)苯基)吡啶-3-醇
  参考文献：
  名称：

  BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS

  摘要：

  本发明涉及一种新型化合物，该化合物在治疗代谢性疾病，特别是Ⅱ型糖尿病及相关疾病方面具有用途，并且还涉及制备和使用这种化合物的方法。

  公开号：

  US20100029650A1

文献信息

• 新型杂环酰胺哌啶类衍生物及其制备方法和在降血糖药物中的应用
  申请人：林剑雄

  公开号：CN113248488A

  公开（公告）日：2021-08-13

  本发明属于药物合成技术领域，尤其涉及新型杂环酰胺哌啶类衍生物和制备方法，及其作为GPR119激动剂在降血糖药物中的应用。通过MTT实验显示，本课题组合成的新型杂环酰胺哌啶类衍生物具有开发降血糖药物的前景。
• Azetidine Derivatives as G-Protein Coupled Receptor (GPR119) Agonists
  申请人：Fyfe Matthew Colin, Thor

  公开号：US20090281076A1

  公开（公告）日：2009-11-12

  Compounds of formula (I) or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful for the treatment of diabetes and as peripheral regulators of satiety, e.g. for the treatment of obesity and metabolic syndrome.

  式(I)的化合物或其药学上可接受的盐是GPR119的激动剂，可用于糖尿病的治疗以及作为外周饱食感调节剂，例如用于肥胖和代谢综合征的治疗。
• Bicyclic compounds and use as antidiabetics
  申请人：GlaxoSmithKline LLC

  公开号：US08101634B2

  公开（公告）日：2012-01-24

  The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.

  本发明涉及一种新型化合物，可用于治疗代谢性疾病，特别是II型糖尿病及相关疾病，并且还涉及制备和使用这种化合物的方法。
• AZETIDINE DERIVATIVES AS G-PROTEIN COUPLED RECEPTOR (GPR119 ) AGONISTS
  申请人：Prosidion Limited

  公开号：EP2010485A1

  公开（公告）日：2009-01-07
• US8101634B2
  申请人：——

  公开号：US8101634B2

  公开（公告）日：2012-01-24