6-(4-氟苯基)-1,3-二氢吲哚-2-酮 | 258831-98-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 6-(4-氟苯基)-1,3-二氢吲哚-2-酮
• 英文名称: 6-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-indole
• 英文别名: 6-(4-fluorophenyl)indolin-2-one；6-(4-Fluoro-phenyl)-1,3-dihydro-indol-2-one；6-(4-fluorophenyl)-2-oxindole；6-(4-Fluorophenyl)-1,3-dihydro-2H-indol-2-one；6-(4-fluorophenyl)-1,3-dihydroindol-2-one
• CAS: 258831-98-0
• 化学式: C₁₄H₁₀FNO
• 分子量: 227.238
• InChiKey: GEBJQECIKGQKJH-UHFFFAOYSA-N

物化性质

• 沸点：
  412.4±45.0 °C(Predicted)
• 密度：
  1.258±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(4-氟苯基)-1,3-二氢吲哚-2-酮 、 3-(3-morpholin-4-yl-propyl)-1,4,5,6,7,8-hexahydro-cyclohepta[b]pyrrole-2-carbaldehyde 在 哌啶 作用下， 以 乙醇 为溶剂， 生成 6-(4-fluorophenyl)-3-[1-[3-(3-morpholin-4-yl-propyl)-1,4,5,6,7,8-hexahydrocyclohepta[b]pyrrol-2-yl]-meth-(Z)-ylidene]-1,3-dihydroindol-2-one
  参考文献：
  名称：

  Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors

  摘要：

  本发明涉及一类吲哚酮化合物，即六氢-环庚-吡咯酮氧吲哚，其作为蛋白激酶抑制剂具有用途。

  公开号：

  US20040186160A1
• 作为产物：
  描述：

  在 四乙基溴化铵 、 溶剂黄146 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 2.0h， 生成 6-(4-氟苯基)-1,3-二氢吲哚-2-酮
  参考文献：
  名称：

  Molybdenum hexacarbonyl mediated synthesis of indolin-2-one & azaindolin-2-one under catalyst free conditions

  摘要：

  Syntheses of indolin-2-ones and azaindolin-2-ones have been realized. The strategy involves the formation of tosylhydrazone from tosylhydrazine and 2-amino aryl or pyridyl aldehydes/ketones which then undergo intramolecular aminocarbonylation to afford indolin-2-ones and azaindolin-2-ones. The generality of the method was demonstrated by synthesizing C3 substituted and unsubstituted indolin-2-one and azaindolin-2-one derivatives. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.09.123

文献信息

• Indolinone derivatives as protein kinase/phosphatase inhibitors
  申请人：——

  公开号：US20020052369A1

  公开（公告）日：2002-05-02

  The present invention relates to certain 2-indolinone compounds which modulate the activity of protein kinases (“PKs”) and phosphatases. The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

  本发明涉及调节蛋白激酶（“PKs”）和磷酸酶活性的某些2-吲哚酮化合物。因此，本发明的化合物在治疗与异常PK活性相关的疾病方面是有用的。还公开了包含这些化合物的药物组合物、利用包含这些化合物的药物组合物治疗疾病的方法以及制备它们的方法。
• Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors
  申请人：Tang Cho Peng

  公开号：US20050032871A1

  公开（公告）日：2005-02-10

  The present invention relates to compounds having the following chemical structure (Formula I): where the substituents R 1 -R 10 are defined herein. The compounds of this invention are useful in treating disorders related to abnormal kinase activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

  本发明涉及具有以下化学结构（式I）的化合物，其中取代基R1-R10在此定义。本发明的化合物在治疗与异常激酶活性相关的疾病方面具有用途。还公开了包含这些化合物的药物组合物、利用包含这些化合物的药物组合物治疗疾病的方法以及制备它们的方法。
• 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
  申请人：——

  公开号：US20020042427A1

  公开（公告）日：2002-04-11

  The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

  该发明涉及某些吲哚酮化合物，它们的合成方法，以及由该发明的吲哚酮化合物组成的组合库。该发明还涉及使用该发明的吲哚酮化合物调节蛋白激酶功能的方法，以及通过调节蛋白激酶功能和相关信号传导途径治疗疾病的方法。
• 3-methylidenyl-2-indolinone modulators of protein kinase
  申请人：Sugen, Inc.

  公开号：US20040024010A1

  公开（公告）日：2004-02-05

  The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

  本发明涉及新型的3-甲基亚烯基-2-吲哚酮化合物及其生理上可接受的盐和前药，这些化合物可调节蛋白激酶的活性，因此预计在预防和治疗蛋白激酶相关的细胞疾病，如癌症方面具有用途。
• 3-Methylidenyl-2-indolinone modulators of protein kinase
  申请人：Sugen, Inc.

  公开号：US06531502B1

  公开（公告）日：2003-03-11

  The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

  本发明涉及新型的3-甲基亚乙烯基-2-吲哚酮化合物及其生理上可接受的盐和前药，其调节蛋白激酶活性，因此预计在预防和治疗蛋白激酶相关的细胞疾病，如癌症方面有用。