GlcN(b1-4)[H2NNH(-2d)]b-Glc

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: GlcN(b1-4)[H2NNH(-2d)]b-Glc
• 英文别名: (2R,3S,4R,5R,6S)-5-amino-6-[(2R,3S,4R,5R,6R)-5-hydrazinyl-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-2-(hydroxymethyl)oxane-3,4-diol
• 化学式: C₁₂H₂₅N₃O₉
• 分子量: 355.34
• InChiKey: ITWRPRPORUTVQB-PMCTYKHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.9
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  213
• 氢给体数：
  9
• 氢受体数：
  12

文献信息

• Anti-MUC16 antibodies and uses thereof
  申请人：MEMORIAL SLOAN KETTERING CANCER CENTER

  公开号：US11066480B2

  公开（公告）日：2021-07-20

  Provided herein are compositions, methods, and uses involving antibodies that immunospecifically bind glycosylated forms of MUC16, a tethered mucin protein. Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer.

  本文提供了涉及抗体的组合物、方法和用途，这些抗体可免疫特异性地结合MUC16（一种系链粘蛋白）的糖基化形式。本文还提供了用于控制、治疗或预防癌症等疾病的用途和方法。
• ANTI-MUC16 ANTIBODIES AND USES THEREOF
  申请人：Memorial Sloan Kettering Cancer Center

  公开号：EP3271398A1

  公开（公告）日：2018-01-24
• [EN] ANTI-MUC16 ANTIBODIES AND USES THEREOF<br/>[FR] ANTICORPS ANTI-MUC16 ET UTILISATIONS
  申请人：MEMORIAL SLOAN KETTERING CANCER CENTER

  公开号：WO2016149368A1

  公开（公告）日：2016-09-22

  Provided herein are compositions, methods, and uses involving antibodies that immunospecifically bind glycosylated forms of MUC16, a tethered mucin protein. Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer.