(R)-(+)-2,2,5,5-tetramethyl-3-hexanol | 79449-64-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-(+)-2,2,5,5-tetramethyl-3-hexanol
• 英文别名: (3R)-2,2,5,5-tetramethylhexan-3-ol
• CAS: 79449-64-2
• 化学式: C₁₀H₂₂O
• 分子量: 158.284
• InChiKey: CFEYPBVKHMZCFR-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-2,2,5,5-tetramethylhex-3-ene 在 甲醇 、 sodium hydroxide 、 双氧水 、 (-)-Monoisopinocampheylborane 作用下， 生成 (S)-2,2,5,5-Tetramethyl-3-hexanol 、 (R)-(+)-2,2,5,5-tetramethyl-3-hexanol
  参考文献：
  名称：

  Hydroboration. 62. Monoisopinocampheylborane; an excellent chiral hydroborating agent for trans-disubstituted and trisubstituted alkenes. Evidence for a strong steric dependence in such asymmetric hydroborations

  摘要：

  DOI：

  10.1021/jo00147a006

文献信息

• HETEROCYCLYL AND CYCLOALKYL SUBSTITUTED THIENO[2,3 d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
  申请人：Barbay J. Kent

  公开号：US20100093723A1

  公开（公告）日：2010-04-15

  This invention relates to a novel thieno[2,3-d]pyrimidine, Z, and its therapeutic and prophylactic uses, wherein X, R 1 and R 2 are defined in the specification. Disorders treated and/or prevented include Parkinson's Disease.

  本发明涉及一种新型的噻吩[2,3-d]嘧啶Z及其治疗和预防用途，其中X、R1和R2在规范中有定义。治疗和/或预防的疾病包括帕金森病。
• High asymmetric induction in the chiral hydroboration of trans-alkenes with isopinocampheylborane. Evidence for a strong steric dependence in such asymmetric hydroborations
  作者：Herbert C. Brown、Prabhakar K. Jadav

  DOI：10.1021/jo00337a060

  日期：1981.11
• BROWN, H. C.;JADHAV, P. K.;MANDAL, A. K., J. ORG. CHEM., 1982, 47, N 26, 5074-5083
  作者：BROWN, H. C.、JADHAV, P. K.、MANDAL, A. K.

  DOI：——

  日期：——
• EXTENDED BETULINIC ACID ANALOGS
  申请人：VIIV HEALTHCARE UK (No.5) LIMITED

  公开号：US20170334945A1

  公开（公告）日：2017-11-23

  Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
• OXOLUPENE DERIVATIVES
  申请人：ViiV Healthcare UK (No.5) Limited

  公开号：US20170334946A1

  公开（公告）日：2017-11-23

  Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.