1-O-(2,3,4,6-tetraacetyl-D-mannoside)-2-bromoethane

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-O-(2,3,4,6-tetraacetyl-D-mannoside)-2-bromoethane
• 英文别名: [(2R,3R,4S,5S)-3,4,5-triacetyloxy-6-(2-bromoethoxy)oxan-2-yl]methyl acetate
• 化学式: C₁₆H₂₃BrO₁₀
• 分子量: 455.257
• InChiKey: WAUIUUNDCFRMRS-WHWZVRATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  1-O-(2,3,4,6-tetraacetyl-D-mannoside)-2-bromoethane 在 sodium hydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 25.0h， 生成 1-O-(2,3,4,6-tetraacetyl-D-mannoside)propane-3-fluoro-3,3-diethyl dicarboxylate
  参考文献：
  名称：

  FLUORINE-CONTAINING WATER SOLUBLE PLATINUM COMPLEXES FOR TUMOR TREATMENT AND PROCESS OF PREPARING SAME

  摘要：

  本发明公开了一种用于肿瘤治疗的含氟高水溶性铂配合物及其制备方法，该铂配合物的化学式为(I)。本发明的含氟铂配合物与临床药物奥沙利铂相比，表现出更优异的细胞毒性和疗效。本发明的设计策略是增强铂配合物的溶解度和稳定性，以便其在临床上使用。

  公开号：

  US20150011740A1
• 作为产物：
  描述：

  甘露糖 在 高氯酸 、 三氟化硼乙醚 作用下， 反应 14.0h， 生成 1-O-(2,3,4,6-tetraacetyl-D-mannoside)-2-bromoethane
  参考文献：
  名称：

  具有触变性和脱水收缩性能的甘露糖修饰复合肽水凝胶及其在利什曼病治疗中的应用

  摘要：

  复合材料的力量：复合水凝胶由自组装短肽和甘露糖缀合的非组装肽制成，用于治疗利什曼病。用甘露糖进行表面装饰可以有效结合寄生虫，从而有效治疗利什曼病。

  DOI：

  10.1002/asia.202200550

文献信息

• WATER SOLUBLE PLATINUM COMPLEXES FOR TUMOR TREATMENT AND PROCESS OF PREPARING SAME
  申请人：GUDUI BIOPHARMA TECHNOLOGY INC.

  公开号：US20150051387A1

  公开（公告）日：2015-02-19

  Disclosed are water-soluble platinum complexes for tumor treatment and preparation method, said platinum complexes being shown as formula (I); The present platinum complexes exhibiting superior cytotoxicity and efficacy compare to the clinical drug oxaliplatin, the design strategy of the present platinum complexes is to enhance the solubility and stability favor its clinical use.

  本文披露了一种用于肿瘤治疗的水溶性铂配合物及其制备方法，所述铂配合物表示为式（I）；本文的铂配合物在细胞毒性和疗效方面优于临床药物奥沙利铂，本文的铂配合物设计策略是增强其溶解性和稳定性，有利于其临床应用。
• Lanthanum Trifluoromethane-sulfonate‐Catalyzed Facile Synthesis of Per‐<i>O</i>‐acetylated Sugars and Their One‐Pot Conversion to <i>S</i>‐Aryl and <i>O</i>‐Alkyl/Aryl Glycosides
  作者：Somnath Dasgupta‡、Vishal Kumar Rajput‡、Bimalendu Roy、Balaram Mukhopadhyay

  DOI：10.1080/07328300701298170

  日期：2007.4.30

  Lanthanum trifluoromethanesulfonate- catalyzed solvent-freeper-O-acetylation with stoichiometric acetic anhydride proceeds in high yield (95%-99%) to afford exclusively pyranose products as anomeric mixtures. Subsequent anomeric substitution employing borontrifluoride etherate and thiols or alcohols furnished the corresponding 1,2-trans-linked thioglycosides and O-glycosides, respectively, in good to excellent overall yield (75%-85%). Alternatively, reaction of free sugars in neat alcohol employing the same catalyst at elevated temperature gives the corresponding 1,2-cis-linked O-glycosides (along with 1,2-trans-linked glycosides as minor product) in good yield (73%-80%). Anomeric mixtures of compounds thus produced were characterized as their per-O-acetylated derivatives.[GRAPHICS]
• Development of convergent synthetic method for saccharide-linked ethynylpyridine foldamers by Huisgen reaction
  作者：Hajime Abe、Hiroki Makida、Masahiko Inouye

  DOI：10.1016/j.tet.2012.02.069

  日期：2012.6

  Based on 'click chemistry', the new convergent synthesis to a variety of saccharide-linked 2,6-pyridylene ethynylene 'ethynylpyridine' foldamers was developed. Ethynylpyridine 6-, 9-, and 12-meric blocks were linked with 1,7-octadiyne linker block by Sonogashira reaction, and joined with azido group-introduced glucoside, galactoside, and mannoside templates by Huisgen reaction. The resulting saccharide-linked ethynylpyridine foldamers exhibited typical circular dichroism to indicate the formation of a helical structure by intramolecular hydrogen bonds. (C) 2012 Elsevier Ltd. All rights reserved.
• FLUORINE-CONTAINING WATER SOLUBLE PLATINUM COMPLEXES FOR TUMOR TREATMENT AND PROCESS OF PREPARING SAME
  申请人：Wang Yiqiang

  公开号：US20150011740A1

  公开（公告）日：2015-01-08

  Disclosed are fluorine-containing highly water-soluble platinum complexes for tumor treatment and preparation method, said platinum complexes being shown as formula (I); The present fluorine-containing platinum complexes exhibiting superior cytotoxicity and efficacy compare to the clinical drug oxaliplatin, the design strategy of the present platinum complexes is to enhance the solubility and stability favor its clinical use.

  本发明公开了一种用于肿瘤治疗的含氟高水溶性铂配合物及其制备方法，该铂配合物的化学式为(I)。本发明的含氟铂配合物与临床药物奥沙利铂相比，表现出更优异的细胞毒性和疗效。本发明的设计策略是增强铂配合物的溶解度和稳定性，以便其在临床上使用。
• Mannose‐Decorated Composite Peptide Hydrogel with Thixotropic and Syneresis Properties and its Application in Treatment of Leishmaniasis
  作者：Payel Dowari、Shalini Roy、Saurav Das、Sumit Chowdhuri、Ritvika Kushwaha、Basab K. Das、Anindita Ukil、Debapratim Das

  DOI：10.1002/asia.202200550

  日期：2022.9.14

  Power of Composite: A composite hydrogel was made of a self-assembling short peptide and a mannose-conjugated non-assembling peptide to tackle Leishmaniasis. The surface decoration with mannose allowed efficient binding of the parasite and thereby allowed effective treatment of Leishmaniasis.

  复合材料的力量：复合水凝胶由自组装短肽和甘露糖缀合的非组装肽制成，用于治疗利什曼病。用甘露糖进行表面装饰可以有效结合寄生虫，从而有效治疗利什曼病。