(phenyl)-[2-(3-nitrophenyl)-2-(2-aminophenylthio)ethyl]-ketone | 497172-11-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (phenyl)-[2-(3-nitrophenyl)-2-(2-aminophenylthio)ethyl]-ketone
• 英文别名: 3-(2-Aminophenyl)sulfanyl-3-(3-nitrophenyl)-1-phenylpropan-1-one
• CAS: 497172-11-9
• 化学式: C₂₁H₁₈N₂O₃S
• 分子量: 378.452
• InChiKey: HBSFQQKLTZDQKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-硝基查耳酮 、 2-氨基苯硫醇 在 animal bone meal 作用下， 以 甲醇 为溶剂， 反应 0.08h， 以94%的产率得到(phenyl)-[2-(3-nitrophenyl)-2-(2-aminophenylthio)ethyl]-ketone
  参考文献：
  名称：

  Animal Bone Meal (ABM): A Novel Natural Catalyst for Thia-Michael Addition

  摘要：

  描述了动物骨粉（ABM）作为天然催化剂在硫-迈克尔加成反应中形成C-S键的制备和使用。这种新的天然异相方法在仅几分钟内就能以非常高的产率生成β-磺酰衍生物。讨论了硫醇衍生物和香豆素上的取代基的影响。

  DOI：

  10.2174/157017810791112397

文献信息

• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：ASTRAZENECA AB

  公开号：WO2004011410A1

  公开（公告）日：2004-02-05

  Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.

  式(I)的化合物：其中变量基团如定义内；用于抑制11βHSD1。
• Ketones
  申请人：Barton John Peter

  公开号：US20050272036A1

  公开（公告）日：2005-12-08

  Compounds of formula (I): wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.

  描述了式(I)的化合物：其中变量基团如定义的那样；用于抑制11βHSD1。
• A natural phosphate and doped-catalyzed Michael addition of mercaptans to α,β-unsaturated carbonyl compounds
  作者：Younes Abrouki、Mohamed Zahouily、Ahmed Rayadh、Bouchaı̈b Bahlaouan、Saı̈d Sebti

  DOI：10.1016/s0040-4039(02)02146-9

  日期：2002.12

  The natural phosphate and doped by potassium fluoride catalyzed Michael addition of mercaptans to chalone derivatives with high yields in few minutes and under mild reaction conditions. Products of undesirable side reactions resulting from 1,2-addition, polymerisation and bis-addition are not observed. The work-up procedure is simplified by simple filtration with the use of natural phosphate alone or doped with potassium fluoride. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Na2CaP2O7, a new catalyst for Michael addition
  作者：Mohamed Zahouily、Younes Abrouki、Ahmed Rayadh

  DOI：10.1016/s0040-4039(02)01846-4

  日期：2002.10

  The synthetic diphosphate Na2CaP2O7 is a new basic catalyst for Michael addition of mercaptans to chalcone derivatives with high yields in a few minutes and mild reaction conditions. Products of undesirable side reactions resulting from 1,2-addition, polymerisation and bis-addition are not observed. (C) 2002 Elsevier Science Ltd. All rights reserved.
• KETONES
  申请人：AstraZeneca AB

  公开号：EP1549600A1

  公开（公告）日：2005-07-06