2-Amino-4-(4-chlor-3-methylphenyl)thiazol | 177356-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Amino-4-(4-chlor-3-methylphenyl)thiazol
• 英文别名: 4-(4-chloro-3-methyl-phenyl)-thiazol-2-yl-amine；4-(4-chloro-3-methylphenyl)-1,3-thiazol-2-amine
• CAS: 177356-72-8
• 化学式: C₁₀H₉ClN₂S
• 分子量: 224.714
• InChiKey: DDCHBSKGUBNYES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Amino-4-(4-chlor-3-methylphenyl)thiazol 在 三乙基硅烷 、 N-羟基-7-氮杂苯并三氮唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-2-Amino-N-[4-(4-chloro-3-methyl-phenyl)-thiazol-2-yl]-propionamide
  参考文献：
  名称：

  Non-peptidic small molecule inhibitors of XIAP

  摘要：

  Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.010

文献信息

• QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS
  申请人：Muthuppalniappan Meyyappan

  公开号：US20090325987A1

  公开（公告）日：2009-12-31

  The present invention provides Quinazolinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明提供了喹唑啉二酮衍生物作为TRPA（瞬时受体电位亚家族A）调节剂。具体来说，本文描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、病况和/或疾病。本文还提供了制备本文描述的化合物的方法、用于合成的中间体、药物组合物以及治疗或预防由TRPA1调节的疾病、病况和/或疾病的方法。
• [EN] PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES FUSIONNÉS À UNE PYRIMIDINE DIONE EN TANT QUE MODULATEURS DE TRPA1
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2010125469A1

  公开（公告）日：2010-11-04

  The present invention is related to novel pyrimidinedione-fused heterocyclic compounds as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及作为TRPA（瞬时受体电位亚家族A）调节剂的新型嘧啶二酮并环杂环化合物。具体地，本文描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、症状和/或疾病。本文还提供了用于制备本文描述的化合物的方法、用于合成的中间体、其药物组成物以及治疗或预防由TRPA1调节的疾病、症状和/或疾病的方法。
• Urea Derivatives Methods For Their Manufacture And Uses Thereof
  申请人：DePrez Pierre

  公开号：US20100240889A1

  公开（公告）日：2010-09-23

  The present invention provides compounds of formula (I): in which R 1 , R′ 1 , R 2 , R′ 2 , R 3 , Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

  本发明提供了式（I）的化合物：其中R1，R′1，R2，R′2，R3，Y和G具有描述中给出的含义，以及它们的制备过程，它们通过药物的方式应用，以及含有它们的制药组合物。
• UREA DERIVATIVES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR
  申请人：DEPREZ Pierre

  公开号：US20120283255A1

  公开（公告）日：2012-11-08

  The present invention provides compounds of formula (I): in which R 1 , R′ 1 , R 2 , R′ 2 , R 3 , and Y have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

  本发明提供了公式（I）的化合物：其中R1，R′1，R2，R′2，R3和Y具有描述中给出的含义，以及它们的制备方法，通过药物的方式应用它们，以及包含它们的制药组合物。
• Urea derivatives, methods for their manufacture, and uses thereof
  申请人：Galapagos SAS

  公开号：EP2354137A1

  公开（公告）日：2011-08-10

  The present invention provides compounds of formula (I): in which R1, R'1, R2, R'2, R3, Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

  本发明提供了式 (I) 的化合物： 中 R1、R'1、R2、R'2、R3、Y 和 G 的含义，以及它们的制备工艺、它们在药物中的应用和含有它们的药物组合物。