[(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-4-(dimethylamino)-5-hydroxy-6-[[(4S,5S,6S,7R,9R,16R)-4-hydroxy-5-methoxy-9,16-dimethyl-2,10-dioxo-7-[2-[[4-(thiadiazol-5-yl)phenyl]methylamino]ethyl]-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-4-(dimethylamino)-5-hydroxy-6-[[(4S,5S,6S,7R,9R,16R)-4-hydroxy-5-methoxy-9,16-dimethyl-2,10-dioxo-7-[2-[[4-(thiadiazol-5-yl)phenyl]methylamino]ethyl]-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate
• 化学式: C₄₉H₇₄N₄O₁₃S
• 分子量: 959.2
• InChiKey: SCQSLVQJKPNNIY-XGPWEUOWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  67
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  246
• 氢给体数：
  4
• 氢受体数：
  18

文献信息

• Macrolide antibacterial compounds
  申请人：——

  公开号：US20040014687A1

  公开（公告）日：2004-01-22

  Macrolide antibacterial compounds having formula (I) 1 and formula (II) 2 and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates employed in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections in a fish or a mammal using the compounds are disclosed.

  本发明涉及具有以下化学式(I)1和化学式(II)2的大环内酯类抗菌化合物和其盐、前药及其盐的制备方法、制备过程中所使用的中间体、含有该化合物的组合物以及使用该化合物进行鱼类或哺乳动物的细菌感染的预防或治疗的方法。