4-(3-chlorobenzoyl)-1-methyl-1H-pyrrole-2-carbaldehyde | 338978-14-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(3-chlorobenzoyl)-1-methyl-1H-pyrrole-2-carbaldehyde
• 英文别名: 4-(3-chlorobenzoyl)-1-methylpyrrole-2-carbaldehyde
• CAS: 338978-14-6
• 化学式: C₁₃H₁₀ClNO₂
• 分子量: 247.67
• InChiKey: HGYPWKCEDGGCLD-UHFFFAOYSA-N

物化性质

• 熔点：
  137-139°C

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  39.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

文献信息

• HETEROCYCLIC COMPOUNDS AS POSITIVE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 (MGLU2 receptor)
  申请人：GENESTE Herve

  公开号：US20080300260A1

  公开（公告）日：2008-12-04

  The present invention relates to heterocyclic compounds which are positive modulators of metabotropic glutamate receptor. The present invention also relates to the use of these compounds for preparing a pharmaceutical composition and to a method of treating a medical disorder, selected from neurological and psychiatric disorders associated with glutamate dysfunction.

  本发明涉及异环化合物，这些化合物是代谢型谷氨酸受体的阳性调节剂。本发明还涉及使用这些化合物制备药物组合物以及治疗神经系统和精神疾病的方法，这些疾病与谷氨酸功能障碍有关。
• Thioxanthine Derivatives and Their Use as Inhibitors of MPO
  申请人：Tiden Anna-Karin

  公开号：US20090149475A1

  公开（公告）日：2009-06-11

  There are disclosed novel compounds of Formula (I) wherein L, R 1 , X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardio- and cerebrovascular atherosclerotic disorders and peripheral artery disease and respiratory disorders.

  本发明公开了新的化合物式（I），其中L、R1、X和Y如规范中所定义，并且其药学上可接受的盐；以及其制备方法、含有它们的组合物和它们在治疗中的应用。这些化合物是MPO酶的抑制剂，因此在神经炎症性疾病、心血管和脑血管动脉粥样硬化性疾病、周围动脉疾病和呼吸系统疾病的治疗或预防中特别有用。
• THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO
  申请人：AstraZeneca AB

  公开号：EP2010535B1

  公开（公告）日：2012-07-11
• HETEROCYCLIC COMPOUNDS AS POSITIVE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 (MGLU2 RECEPTOR)
  申请人：Abbott GmbH & Co. KG

  公开号：EP2167464A1

  公开（公告）日：2010-03-31
• US8026244B2
  申请人：——

  公开号：US8026244B2

  公开（公告）日：2011-09-27