(3R,4S,5R)-2-(6-amino-8-bromopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (3R,4S,5R)-2-(6-amino-8-bromopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 化学式: C₁₀H₁₂BrN₅O₄
• 分子量: 346.14
• InChiKey: VJUPMOPLUQHMLE-LZGMGDPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2360166A1

  公开（公告）日：2011-08-24

  The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.

  本发明提供的核苷衍生物是 RNA 依赖性 RNA 病毒聚合酶的抑制剂。这些化合物是 RNA 依赖性 RNA 病毒复制的抑制剂，可用于治疗 RNA 依赖性 RNA 病毒感染。它们作为丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂、HCV复制的抑制剂和/或治疗丙型肝炎感染特别有用。本发明还描述了含有此类核苷衍生物的药物组合物，这些药物组合物可单独使用，也可与其他对 RNA 依赖性 RNA 病毒感染（尤其是 HCV 感染）具有活性的药物组合使用。本发明还公开了用本发明的核苷衍生物抑制RNA依赖性RNA聚合酶、抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。