4-amino-1-[(2R,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-amino-1-[(2R,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
• 化学式: C10H14N6O5
• 分子量: 298.26
• InChiKey: XMUPVBWEKPRGQO-UCVUIJOESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION
  申请人：Devos Rene Robert

  公开号：US20100003213A1

  公开（公告）日：2010-01-07

  The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
• 4'-Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
  申请人：Martin Joseph Armstrong

  公开号：US20100004192A1

  公开（公告）日：2010-01-07

  The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
• US6784166B2
  申请人：——

  公开号：US6784166B2

  公开（公告）日：2004-08-31
• US7608601B2
  申请人：——

  公开号：US7608601B2

  公开（公告）日：2009-10-27
• US7915232B2
  申请人：——

  公开号：US7915232B2

  公开（公告）日：2011-03-29