methyl 4-(2,3-dioxoindolin-1-yl)-4-oxo-butanoate | 1315270-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: methyl 4-(2,3-dioxoindolin-1-yl)-4-oxo-butanoate
• 英文别名: Methyl 4-(2,3-dioxoindol-1-yl)-4-oxobutanoate；methyl 4-(2,3-dioxoindol-1-yl)-4-oxobutanoate
• CAS: 1315270-95-1
• 化学式: C₁₃H₁₁NO₅
• 分子量: 261.234
• InChiKey: HGTULRGZUQWMDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  80.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  三(2-氨基乙基)胺 、 methyl 4-(2,3-dioxoindolin-1-yl)-4-oxo-butanoate 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以28%的产率得到Methyl 4-[2-[2-[2-[bis[2-[[2-[2-[(4-methoxy-4-oxobutanoyl)amino]phenyl]-2-oxoacetyl]amino]ethyl]amino]ethylamino]-2-oxoacetyl]anilino]-4-oxobutanoate
  参考文献：
  名称：

  Synthesis of dendrimeric N-glyoxylamide peptide mimics

  摘要：

  A range of peptidomimetic dendrimers based on 1,3,5-benzenetricarbonyl trichloride and tris(2-aminoethyl)amine central cores has been synthesised through the facile ring-opening of N-acylisatins with amino acids, alcohols and other amines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.019
• 作为产物：
  描述：

  靛红 、 丁二酸单甲酯酰氯 在 sodium hydride 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.75h， 以60%的产率得到methyl 4-(2,3-dioxoindolin-1-yl)-4-oxo-butanoate
  参考文献：
  名称：

  Synthesis of dendrimeric N-glyoxylamide peptide mimics

  摘要：

  A range of peptidomimetic dendrimers based on 1,3,5-benzenetricarbonyl trichloride and tris(2-aminoethyl)amine central cores has been synthesised through the facile ring-opening of N-acylisatins with amino acids, alcohols and other amines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.019

文献信息

• Facile ring-opening of N-acylisatins for the development of novel peptidomimetics
  作者：Wai Ching Cheah、Kasey Wood、David StC Black、Naresh Kumar

  DOI：10.1016/j.tet.2011.07.036

  日期：2011.9

  A range of novel mono- and bis-glyoxylamide peptidomimetics were prepared via the facile ring-opening of N-acylisatins with amino acids and peptide derivatives. The ring-opening of N-acylisatins with dipeptides and tripeptides was discovered to be the most efficient strategy for the synthesis of second and third generation glyoxylamides. (C) 2011 Elsevier Ltd. All rights reserved.
• Synthesis of dendrimeric N-glyoxylamide peptide mimics
  作者：Thanh Le、Wai Ching Cheah、Kasey Wood、David St.C. Black、Mark D. Willcox、Naresh Kumar

  DOI：10.1016/j.tetlet.2011.05.019

  日期：2011.7

  A range of peptidomimetic dendrimers based on 1,3,5-benzenetricarbonyl trichloride and tris(2-aminoethyl)amine central cores has been synthesised through the facile ring-opening of N-acylisatins with amino acids, alcohols and other amines. (C) 2011 Elsevier Ltd. All rights reserved.