2-[(2S,3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-phenylmethoxyoxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(2S,3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-phenylmethoxyoxan-3-yl]acetamide
• 化学式: C₁₅H₂₁NO₆
• 分子量: 311.33
• InChiKey: OHYWSENIRAXOPX-LWOQNUMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• METHODS FOR INDUCING OREXIN NEURONS AND AGENT FOR TREATING NARCOLEPSY OR EATING DISORDER
  申请人：THE UNIVERSITY OF TOKYO

  公开号：US20140349964A1

  公开（公告）日：2014-11-27

  The invention provides a method for producing an orexin neuron by culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine and optionally in the presence of at least one inhibitor selected from the group consisting of a Sirtuin 1 inhibitor and an O-linked β-N-acetylglucosamine transferase inhibitor. The invention also provides a therapeutic agent for narcolepsy or eating disorders, such as anorexia, containing N-acetyl-D-mannosamine, which is based on the induction of orexin neuron in vivo.
• US9480695B2
  申请人：——

  公开号：US9480695B2

  公开（公告）日：2016-11-01