6-乙基十一烷-6-醇 | 5340-50-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-乙基十一烷-6-醇
• 英文名称: 6-ethylundecan-6-ol
• 英文别名: Aethyl-dipentyl-carbinol；6-Aethyl-undecan-6-ol
• CAS: 5340-50-1
• 化学式: C₁₃H₂₈O
• 分子量: 200.365
• InChiKey: IIJJOKKLBVILSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2905199090

反应信息

• 作为反应物：
  描述：

  6-乙基十一烷-6-醇 在 碘 作用下， 生成 (E)-6-ethylundec-5-ene
  参考文献：
  名称：

  Whitmore; Williams, Journal of the American Chemical Society, 1933, vol. 55, p. 408

  摘要：

  DOI：
• 作为产物：
  描述：

  正戊基溴化镁 、 丙酸 在 乙醚 、 苯 作用下， 生成 6-乙基十一烷-6-醇
  参考文献：
  名称：

  The Preparation of Some Tertiary Alcohols by the Addition of Organic Acids to Grignard Reagents

  摘要：

  DOI：

  10.1021/ja01211a504

文献信息

• Diarylalkanes as potent inhibitors of binuclear enzymes
  申请人：Jia Qi

  公开号：US20050267047A1

  公开（公告）日：2005-12-01

  The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

  本发明实施了一种策略，将酶抑制测定与化学去重复过程相结合，以识别活性植物提取物和特定化合物——二芳基烷烃和/或二芳基醇，这些化合物特异性地抑制双核酶功能。本发明包括由一种或多种二芳基烷烃和/或二芳基醇组成的物质组合物，其抑制双核酶的活性，特别是酪氨酸酶，并防止黑色素过度产生。本发明还提供了一种抑制双核酶活性的方法，特别是酪氨酸酶，以及一种预防和治疗与双核酶功能相关的疾病和病况的方法。本发明还包括一种预防和治疗黑色素过度产生以及与之相关的皮肤疾病和病况的方法。预防和治疗与双核酶功能和黑色素过度产生相关的疾病和病况的方法包括向需要的宿主施用由一种或多种植物合成和/或分离的一种或多种二芳基烷烃和/或二芳基醇组成的组合物的有效量，以及药用载体。
• A Grignard-Type Phase-Vanishing Method: Generation of Organomagnesium Reagent and Its Subsequent Addition to Carbonyl Compounds
  作者：Hiroshi Matsubara、Yuki Niwa、Ryosuke Matake

  DOI：10.1055/s-0034-1380381

  日期：——

  A quadraphasic phase-vanishing system comprised of diethyl ether, magnesium, perfluoropolyether, and iodoalkane efficiently generated the corresponding Grignard reagents, which subsequently added to carbonyl compounds in the ether layer to afford alkylated alcohols in good yields.

  由乙醚、镁、全氟聚醚和碘代烷烃组成的四相相消失系统有效地生成了相应的格氏试剂，随后将其添加到醚层中的羰基化合物中，以良好的收率提供烷基化醇。
• DIARYLALKANES AS POTENT INHIBITORS OF BINUCLEAR ENZYMES
  申请人：Unigen, Inc.

  公开号：US20140371491A1

  公开（公告）日：2014-12-18

  The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

  本发明实施了一种策略，将酶抑制测定与化学去重过程相结合，以鉴定活性植物提取物及其中特定化合物——二芳基烷烃和/或二芳基烷醇，其特异性抑制双核酶功能。本发明包括由一种或多种二芳基烷烃和/或二芳基烷醇组成的物质组合物，其抑制双核酶的活性，特别是酪氨酸酶，从而防止黑色素过度产生。本发明还提供了一种抑制双核酶活性的方法，特别是酪氨酸酶，并提供了一种预防和治疗与双核酶功能相关的疾病和病症的方法。本发明还包括一种预防和治疗黑色素过度产生及其相关皮肤疾病和病症的方法。预防和治疗与双核酶功能和黑色素过度产生相关的疾病和病症的方法包括向需要的宿主施用一种由一种或多种从一种或多种植物中合成和/或分离出的二芳基烷烃和/或二芳基烷醇组成的组合物的有效量，以及药学上可接受的载体。
• Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
  申请人：Unigen Pharmaceuticals, Inc.

  公开号：EP2108370A1

  公开（公告）日：2009-10-14

  The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.; This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.

  本发明提供了一种由两类特定化合物--自由-B-环黄酮和黄烷--的混合物组成的新型物质组合物，用于预防和治疗由COX-2和5-LO途径介导的疾病和病症。本发明进一步提供了一种同时抑制环氧化酶-2（COX-2）和5-脂氧合酶（5-LO）以及减少COX-2 mRNA产生的新方法。最后，本发明包括一种减肥和控制血糖的方法。本发明的方法包括向有需要的宿主施用有效量的本发明组合物和药学上可接受的载体。 本发明一般涉及预防和治疗由环氧化酶-2 (COX-2)和5-脂氧合酶(5-LO)途径介导的疾病和病症，包括但不限于缓解与骨关节炎、类风湿性关节炎等疾病相关的关节不适和疼痛，以及因过度使用而导致的其他损伤。
• Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia
  申请人：UNIGEN PHARMACEUTICALS, INC.

  公开号：US20030180402A1

  公开（公告）日：2003-09-25

  The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.

  本发明提供了一种同时抑制环氧化酶COX-2和5-脂氧合酶（5-LO）的新方法。同时双重抑制 COX-2 和 5-LO 的方法包括向有需要的宿主施用一种组合物，该组合物含有从金合欢属植物中的一种植物或多种植物中分离出来的单个黄酮和/或多种黄酮的混合物。本发明还包括预防和治疗 COX-2 和 5-LO 介导的疾病和病症的新方法。预防和治疗COX-2和5-LO介导的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，该组合物包含从金合欢属植物中的单个植物或多个植物中分离的单个黄素和/或多个黄素的混合物以及药学上可接受的载体。本发明包括一种从金合欢属植物中分离和纯化对COX-2和5-LO具有双重特异性的黄素组合物的方法。